639808-04-1Relevant articles and documents
The Use of a Mannitol-Derived Fused Oxacycle as a Combinatorial Scaffold
Timmer, Mattie S. M.,Verdoes, Martijn,Sliedregt, Leo A. J. M.,Van Der Marel, Gijsbert A.,Van Boom, Jacques H.,Overkleeft, Herman S.
, p. 9406 - 9411 (2003)
An efficient and high-yielding solid-phase synthesis of a small library of compounds containing a cis-fused pyranofuran structural motive is descibed. With use of the cheap and readily available D-(+)-mannitol, a highly functionalized sugar template was synthesized and immobilized on a solid support via an olefinic linker. Modification of this two-point molecular scaffold and subsequent ring-closing metathesis/cleavage gave access to a series of functionalized conformationally constrained fused oxacycles.
