639814-87-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 141435-12-3 (1S,6S)-6-(2-oxooxazolidine-3-carbonyl)-cyclohex-3-enecarboxylic acid methyl ester 
• 253454-00-1 (1S,2S)-Cyclohex-4-ene-1,2-dicarboxylic acid monomethyl ester 

Downstream Products

• 639814-88-3 (1S,2S)-2-methanesulfonylaminocyclohexanecarboxylic acid (1-hydroxymethyl-2-methylpropyl)-amide 
• 639814-86-1 (1S,2S)-2-methanesulfonylaminocyclohexanecarboxylic acid 

Relevant academic research and scientific papers

Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions

The recently developed (cyclohexylsulfonylamino)oxazoline (CHAOx) ligand was found to provide high ee's and consistent reaction rates in the asymmetric diethylzinc addition to benzaldehyde over a remarkably large loading range of 0.05-10 mol%. Turnover numbers of 1000-2000 can be explained by the absence of a nonlinear effect and the formation of a catalytically active monomer complex. Substituents at the nitrogen donor atoms of the bidentate ligand prevent zinc-complex dimerization.