6399-14-0

Upstream product

• 74-88-4 methyl iodide 
• 91-16-7 1,2-dimethoxybenzene 
• 4676-42-0 α,β-dimethyl-γ-(3,4-dimethoxyphenyl) butyrolactone 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 75-05-8 acetonitrile 
• 93-16-3 Methylisoeugenol 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 3569-00-4 (+/-)-trans-4-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-2,3-dimethylnaphthalene 
• 521-54-0 (±)-galbulin 
• 4131-03-7 bis(3,4-dimethoxyphenyl)methanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 74084-26-7 3,3',4,4'-tetramethoxybenzhydrole 
• 98333-30-3 5,5-bis-(3,4-dimethoxy-phenyl)-3,4-dimethyl-dihydro-furan-2-one 

Downstream Products

• 521-54-0 (±)-galbulin 
• 521-54-0 1β-(3,4-dimethoxyphenyl)-2β,3α-dimethyl-6,7-dimethoxytetralin 

Relevant academic research and scientific papers

Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Abstract Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (-)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synt

Stereocontrolled syntheses of tetralone- and naphthyl-type lignans by a one-pot oxidative [3,3] rearrangement/friedel-crafts arylation

The development of a stereoselective one-pot oxidative [3,3] sigmatropic rearrangement/Friedel-Crafts arylation that provides enantioenriched benzhydryl compounds is reported. The utility of this new transformation is demonstrated by the concise synthesis of several tetralone- and naphthyl-type lignan natural products, many of which display anti-malarial activity.

Collective synthesis of several 2,7′-cyclolignans and their correlation by chemical transformations

Collective synthesis of anti-malarial 2,7′-cyclolignans has been stereoselectively achieved employing (±)-cyclogalgravin (2) as a linchpin through a series of functional group conversions, including redox reactions. Interestingly, 2 can be correlated with

Studies on chromium trioxide-based oxidative coupling reagents and synthesis of lignan-cagayanone

Oxidation of 1-arylprop-1-enes by using the reagent system CrO3-HClO4- CH3CN at 0-5°C gave seven products from methyl isoeugenol, five from ethyl isoeugenol, four from benzyl isoeugenol, and five from isosafrole. Cagayanone was obtained from isosafrole in one step. The structures of the products were elucidated and the mechanism of their formation is discussed.

New Reagent System containing CrO3 and Syntheses of Neo-lignans

Oxidations of 1-arylprop-1-enes by the new reagent systems, CrO3-HBF4-MeCN or CrO3-HClO4-MeCN gave the 4-aryltetralones (1a) and (1c), and the tetrahydrofuran (3) which are precursor molecules for aryltetrahydronaphthalene and tetrahydrofuran neo-lignans.

New Reagent Systems Containing CrO3 Provide Precursors for Syntheses of Neo-lignans

Oxidations of 1-aryl-1-propenes with new reagent systems, CrO3-HBF4-MeCN and CrO3-HClO4-MeCN, gave the 4-aryltetralones 1a and 1c, and the tetrahydrofuran 4, which are precursor molecules for aryltetrahydronaphthalene and tetrahydrofuran neo-lignans.Keywords - reagent system: chromium trioxide, neo-lignan; aryltetrahydronaphthalene; tetrahydrofuran