64001-48-5

Upstream product

• 118-92-3 anthranilic acid 
• 7719-09-7 thionyl chloride 

Downstream Products

• 123767-94-2 anthraniloyl chloride ; hydrochloride 
• 32212-38-7 2-amino-N-(4-methylphenyl)benzamide 
• 340291-84-1 2-(2-amino-benzoylamino)-5-benzyloxybenzoic acid methyl ester 
• 49854-16-2 methyl 2-(2-aminobenzoylamino)benzoate 
• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 
• 4425-23-4 7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one 
• 340291-81-8 2-[2-(N-benzyloxycarbonyl-L-alanyl)benzoylamino]benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 331758-78-2 3-(4-methylphenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one 
• 15351-42-5 dianthranilide 
• 1009318-28-8 3-(2-methoxyphenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one 
• 18189-02-1 propan-2-yl 2-aminobenzoate 
• 21132-01-4 2,3-diphenyl-2,3-dihydro-1H-quinazolin-4-one 
• 63384-39-4 3-(4-chlorophenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one 

Relevant academic research and scientific papers

On the reaction of anthranilic acid with thionyl chloride: The actual structure of 'Kametani's sulfinamide anhydride'

Despite previous reports, no sulfinamide anhydride is formed from the reaction of anthranilic acid with thionyl chloride, the actual product being 2-sulfinylaminobenzoyl chloride. This excludes iminoketene formation in the reactions of this activated form

Thioester-appended organosilatranes: Synthetic investigations and application in the modification of magnetic silica surfaces

The present investigation discloses a series of new organosilicon derivatives (3a-k) tailored with substituted benzoic acid modules (1a-k) via thioesterification with 3-mercaptopropylsilatrane (MPS). Product formation was authenticated using elemental analyses and different spectroscopic methods comprising FT-IR, NMR [1H, 13C] and LC-MS (Q-TOF). Thereafter, complete structural elucidation of compounds 3c and 3f was achieved by the single crystal X-ray technique. Photo-electronic inspection of all compounds by UV-Vis spectroscopy revealed their sensitivity towards substitution patterns. In addition, this is the first time that the potential of a silatranyl moiety has been tested for the modification of a silica surface pre-decorated with a magnetite core. The synthesis was achieved through a facile methodology involving chemical bonding at each stage, which proceeded without any external surfactant or template. The course of the reaction was followed by FT-IR, UV-Vis, XRD, TEM, FESEM, EDX and TGA techniques. Furthermore, the hybrid nanomaterial possessed significant sensorial ability toward copper ions, which makes the present protocol favourable for the construction of a new class of chelating ligands with an in-built multifunctional nanodevice.

Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis

Natural products sclerotigenin, pegamine, deoxyvasicinone, mackinazolinone, and rutaecarpine were synthesized. Core quinazolinone structures were constructed via Ir catalysis. The Royal Society of Chemistry 2012.

First total synthesis of (-)-Circumdatin H, a novel mitochondrial NADH Oxidase inhibitor

An efficient and highly convergent synthesis of the mitochondrial NADH oxidase inhibitor (-)-circumdatin H is described. The strategy employs the intramolecular Eguchi aza-Wittig protocol as a key step to install the crucial central core BC ring system, leading to the first total synthesis of the target molecule. Georg Thieme Verlag Stuttgart · New York.

On the reaction of anthranilic acid with thionyl chloride: Iminoketene intermediate formation

2-(Sulfinylamino) benzoyl chloride is formed on treating anthranilic acid with thionyl chloride. The formation of iminoketene intermediate from 2-(sulfinylamino) benzoyl chloride is established and the reactions carried out using the intermediate are described.

Synthesis and structure-activity relationships of vasicine analogues as bronchodilatory agents

The series of vasicine (1) analogues, an alkaloid from Adhatoda vasica Nees., were synthesized with changes in A, B or C rings. Compounds 3-19 were evaluated for in vitro bronchodilatory activity using isolated guinea pig tracheal chain. Compounds 3-8 were also synthesized in good yields using microwave-mediated synthesis under solvent free conditions. Compounds 5 and 8 with seven-member C ring were more active than etofylline and caused 100% relaxation of both the histamine and acetylcholine pre-contracted guinea pig tracheal chain. The structure-activity relationship studies showed that the quinazoline and oxo functionalities were essential for activity. The compounds without C ring and instead having aliphatic and phenyl substitutions in B ring showed relaxation against histamine pre-contracted tracheal chain only, 2-methyl substituted analogues, 12 and 13, being most active with 100% relaxation effect. Birkhaeuser Boston 2006.

Total synthesis of the cytotoxic alkaloid luotonin A

The structure of luotonin A was unambiguously confirmed by total synthesis. Deprotonation of 3-oxo-1H-pyrrolo[3,4-b]quinoline gave an anion which was coupled with 2-sulfinylaminobenzoyl chloride (prepared by reaction of anthranilic acid with thionyl chlor

Synthesis of 2'- and 2''-O-Acylated Maltotriosides as Potential Fluorescence-quenched Substrates for α-Amylase

Several 2'- and 2''-O-acylated maltotrioside derivatives have been prepared as substrates for use in fluorescence-quenched assays of α-amylase.These maltotriosides carry a quenching group at the reducing and a fluorescen