64011-01-4Relevant academic research and scientific papers
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells
Del Bello, Fabio,Bonifazi, Alessandro,Giorgioni, Gianfabio,Quaglia, Wilma,Amantini, Consuelo,Morelli, Maria Beatrice,Santoni, Giorgio,Battiti, Francisco O.,Vistoli, Giulio,Cilia, Antonio,Piergentili, Alessandro
, p. 461 - 473 (2019)
A series of derivatives obtained by moving the aromatic moiety on the 1,4-dioxane ring of compounds 1–3 from position 6 to position 2 or 3 was prepared and evaluated for the affinity for 5-HT1A receptor (5-HT1AR) and α1-ad
Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC-Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones
Janssen-Müller, Daniel,Schedler, Michael,Fleige, Mirco,Daniliuc, Constantin G.,Glorius, Frank
, p. 12492 - 12496 (2015/10/12)
A highly enantioselective intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin-substituted aldehydes (up to 99% ee). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC-catalyzed hydroacylation reaction for the first time. 100% Organic: A highly enantioselective N-heterocyclic carbene (NHC)-catalyzed intramolecular hydroacylation of aromatic and, more interestingly, aliphatic aldehydes with unactivated olefins offers access to a range of cyclic α-chiral ketones bearing quaternary centers. The reaction was found to be highly robust and proceeds with excellent yield in the presence of a diverse range of functional groups.
