640234-75-9

Upstream product

• 2628-16-2 p-acetoxystyrene 
• 200405-33-0 (S)-(+)-acetic acid 4-(2-benzyloxycarbonylamino-1-hydroxy-ethyl)phenyl ester 
• 640234-74-8 acetic acid 4-(2-benzyloxycarbonylamino-1-(S)-methoxy-ethyl)phenyl ester 
• 851714-36-8 [2-(4-hydroxy-phenyl)-2-(S)-methoxy-ethyl]carbamic acid benzyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATMENT OF CANCER AND MODULATION OF PROGRAMMED CELL DEATH FOR MELANOMA AND OTHER CANCER CELLS

Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

The selective induction of death in cancer cells is a major challenge in modern medicine. In this communication we describe the synthesis of an 88-membered combinatorial library, and the subsequent evaluation of these compounds for their ability to selectively induce apoptosis in cancerous cells. A compound was identified from the library that induces apoptosis in U-937 and HL-60 cell lines. This compound is a remarkably selective pro-apoptotic agent for these cancer cell lines, as it does not induce significant death in noncancerous white blood cells, even at concentrations as high as 1000 μM. Copyright