Cas 640294-72-0,4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate

640294-72-0

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Basic information

Product Name: 4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate
Synonyms: 4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate
CAS NO:640294-72-0
Molecular Formula:
Molecular Weight: 498.536
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate(CAS DataBase Reference)
NIST Chemistry Reference: 4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate(640294-72-0)
EPA Substance Registry System: 4-nitrophenyl-((1S)-1-{[(3a'R,6a'S)-1'-(cyclopropylcarbonyl)-2'-oxo-hexahydro-4'H-spiro[cyclobutane-1,3'-pyrrolo[3,2b]pyrrol]-4'-yl]carbonyl}-2-methylpropyl)carbamate(640294-72-0)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 640294-72-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 640294-72-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,0,2,9 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 640294-72:
(8*6)+(7*4)+(6*0)+(5*2)+(4*9)+(3*4)+(2*7)+(1*2)=150
150 % 10 = 0
So 640294-72-0 is a valid CAS Registry Number.

640294-72-0Upstream product

7693-46-1 4-Nitrophenyl chloroformate

640294-72-0Downstream Products

640294-72-0Relevant academic research and scientific papers

Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease

Andrews, David M.,Barnes, Michael C.,Dowle, Mike D.,Hind, S. Lucy,Johnson, Martin R.,Jones, Paul S.,Mills, Gail,Patikis, Angela,Pateman, Tony J.,Redfern, Tracy J.,Robinson, J. Ed,Slater, Martin J.,Trivedi, Naimisha

, p. 4631 - 4634 (2003)

(Matrix presented) In this, the second of two Letters, the optimization of the pyrrolidine-5,5-trans-lactam template (exemplified by 1a) as a mechanism-based inhibitor of hepatitis C NS3/4A protease is described. Right Boxn analysis of cassette dosing screening pharmacokinetic data was used to rapidly categorize the compounds. GW0014 (compound 4d) emerged as the compound displaying an optimal balance of biochemical and replicon potency, along with low i.v. clearance in the dog.

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease

Slater, Martin J.,Amphlett, Elizabeth M.,Andrews, David M.,Bamborough, Paul,Carey, Seb J.,Johnson, Martin R.,Jones, Paul S.,Mills, Gail,Parry, Nigel R.,Somers, Donald O'N.,Stewart, Alan J.,Skarzynski, Tadeusz

, p. 4627 - 4630 (2007/10/03)

(Matrix presented) In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonstrated a

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