640294-74-2Relevant academic research and scientific papers
Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease
Slater, Martin J.,Amphlett, Elizabeth M.,Andrews, David M.,Bamborough, Paul,Carey, Seb J.,Johnson, Martin R.,Jones, Paul S.,Mills, Gail,Parry, Nigel R.,Somers, Donald O'N.,Stewart, Alan J.,Skarzynski, Tadeusz
, p. 4627 - 4630 (2003)
(Matrix presented) In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonstrated a
