64036-71-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzothiazolamine,4,6-dimethyl-(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs. Its unique chemical structure and potential biological activities make it a promising candidate for further research and development in the pharmaceutical field.
Used in Agrochemical Industry:
2-Benzothiazolamine,4,6-dimethyl-(9CI) is used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural chemicals. Its potential applications in this industry can help improve crop protection and increase agricultural productivity.
Used in Organic Synthesis:
2-Benzothiazolamine,4,6-dimethyl-(9CI) is used as a building block in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the creation of new organic molecules for various applications, including materials science, chemical research, and specialty chemicals.
Used in Biological Research:
2-Benzothiazolamine,4,6-dimethyl-(9CI) is used in biological research to study its potential anti-tumor and anti-viral properties. Further investigation into its biological activities can lead to the discovery of new therapeutic agents and contribute to the advancement of medical science.

InChI:InChI=1/C9H10N2S/c1-5-3-6(2)8-7(4-5)12-9(10)11-8/h3-4H,1-2H3,(H2,10,11)

Upstream product

• 16738-20-8 (2,4-dimethylphenyl)thiourea 
• 540-72-7 sodium thiocyanide 
• 95-68-1 2,4-Xylidine 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 1267448-30-5 6,8-dimethyl-4-phenyl-2H-pyrimido[2,1-b]benzothiazol-2-one 
• 1422007-17-7 (4′,6′-dimethylbenzothiazol-2-yl)-2-(4′-chlorostyryl)quinazolin-4(3H)-one 
• 1422007-13-3 3-(4′,6′-dimethylbenzothiazol-2-yl)-2-(4′-methoxystyryl)quinazolin-4(3H)-one 
• 748777-75-5 N-benzyl-4,6-dimethylbenzo[d]thiazol-2-amine 

Relevant academic research and scientific papers

Visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN to 2-aminobenzothiazoles without photocatalyst

By using ambient air as the oxidant and malic acid as the promoter, a practical method for the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of aromatic amines and KSCN in eco-friendly bis(methoxypropy)ether under metal-, hazardous additive-, photocatalyst-free conditions was established.

Efficient and facile protocol for one-pot synthesis of 2-amino-substituted benzothiazoles catalyzed by nano-BF3/SiO2 under mild conditions

Abstract: A highly efficient and simple protocol for the preparation of 2-aminobenzothiazoles through the reaction of potassium thiocyanate and substituted anilines in the presence of nano-BF3/SiO2 as a reusable heterogeneous catalyst is described. In this method, all of the 2-amino-substituted benzothiazoles were obtained in high to excellent yields and short reaction times under mild conditions. The structures of the resulting products were characterized and confirmed by melting point, FT-IR, 1H NMR and 13C NMR techniques. Graphical Abstract: A highly efficient and simple protocol for the preparation of 2-aminobenzothiazoles by reaction of potassium thiocyanate and substituted anilines in the presence of nano-BF3/SiO2 as a reusable heterogeneous catalyst is described.[Figure not available: see fulltext.]

A novel system for the synthesis of 2-aminobenzthiazoles using sodium dichloroiodate

2-Aminobenzthiazole is a privileged scaffold with a range of biological activities. However, to date, an efficient protocol for the synthesis of this ring system using aniline as a starting material has been lacking. Herein, for the first time, we describe a highly efficient and mild protocol for the synthesis of 2-aminiobenzthiazole using NaICl Georg Thieme Verlag Stuttgart ? New York.

Design and synthesis of new derivatives of 3H-quinazolin-4-one as potential anticonvulsant agents

As a part of systematic investigation on synthesis and biological activities, some new derivatives of 2-ethyl-3-(substituted benzothiazole- 2′-yl)-[3H]-quinazolin-4-ones 3 have been synthesized, and the structures of the compounds were confirmed by elemental analysis and spectral data. The newly synthesized derivatives are then screened for anticonvulsant activity by maximal electroshock method. Copyright

Synthesis and antimicrobial activity of 2H-pyrimido[2,1-b]benzothiazol-2- ones

4-Phenyl-2H-pyrimido[2,1-b]benzothiazol-2-ones have been synthesized in quantitative yields by the reaction of 2-aminobenzothiazoles with alkynoic acid. The antimicrobial activity of the synthesized compounds was tested against bacterial species, Bacillus coagulans, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. The synthesized compounds have shown significant activity against microorganisms which can be correlated with the fused heterocyclic systems.

Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents

A series of substituted 2-aminobenzothiazoles and derivatives useful for treating cerebrovascular disorders are disclosed. Also disclosed is a new method for treating such disorders.