64036-72-2

Usage

Uses

Used in Organic Synthesis:
4-methylbenzothiazol-2-amine monohydrochloride is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Industry:
As a building block for pharmaceuticals, 4-methylbenzothiazol-2-amine monohydrochloride is utilized in the development of new drugs, owing to its chemical properties that can be incorporated into medicinal compounds.
Used in Dye Industry:
4-methylbenzothiazol-2-amine monohydrochloride serves as a dye intermediate, playing a crucial role in the production of various dyes that have applications in different industries, including textiles and printing.
Used in Production of Fluorescent Whitening Agents:
4-methylbenzothiazol-2-amine monohydrochloride is employed in the creation of fluorescent whitening agents, which are used to enhance the brightness and whiteness of various products.
Used in Neuroscience Research:
In the field of neuroscience, 4-methylbenzothiazol-2-amine monohydrochloride is used as a fluorescent label for the visualization of neurons and other cells in biological tissues, aiding researchers in studying cellular structures and functions.

InChI:InChI=1/C8H8N2S.ClH/c1-5-3-2-4-6-7(5)10-8(9)11-6;/h2-4H,1H3,(H2,9,10);1H

Upstream product

• 1477-42-5 4-methyl-1,3-benzothiazol-2-amine 
• 614-78-8 o-tolylthiourea 
• 95-53-4 o-toluidine 

Downstream Products

• 38338-21-5 6-chloro-4-methylbenzo[d]thiazol-2-amine 
• 20174-68-9 4-methyl-2-hydrazinobenzothiazole 

Relevant academic research and scientific papers

Preparation and synthesis method of thiazoline hydrochloride

The invention provides 2-amino-4-methylbenzothiazole hydrochloride. A chemical formula is as follow: a formula (I) is shown in the description. A synthesis method of the compound I comprises the following steps: weighing 0.3292g of 2-amino-4-methylbenzothiazole and adding into a 100mL beaker; adding 20mL of anhydrous methanol and continuously stirring; after a solid medicine is dissolved, slowly dropwise adding 1.5mL of concentrated hydrochloric acid; after uniformly stirring, adding 0.2379g of cobalt chloride hexahydrate; after the cobalt chloride hexahydrate is dissolved, slowly adding 10mLof anhydrous ethyl ether (keeping stirring in a whole process); then standing for about 4 days to obtain a colorless and transparent crystal; filtering the crystal and washing with an acidic methanolsolution; drying for 30min in vacuum to obtain a colorless and transparent rhombus-shaped crystal. According to application of the compound I, the compound I has relatively good catalytic performancein Henry reaction of benzaldehyde, and on the benzaldehyde, and the conversion rate reaches 53 percent and 88 percent respectively.

Production process for 4-methyl-2-hydrazinobenzothiazole

4-methyl-2-hydrazinobenzothiazole is an important intermediate for synthesis of tricyclazole, and the tricyclazole is a main drug for preventing and controlling rice blast and a high-efficiency systemic fungicide, and has high biological activity, a unique action mechanism and special effects on preventing and controlling the rice blast. A current synthetic technology has low reaction efficiency and not high product purity, and produces more three industrial waste (waste water, waste gas and solid waste). The invention overcomes the above disadvantages to provide a production process for the 4-methyl-2-hydrazinobenzothiazole; and the process is realized through the following steps: 1, weighing raw materials for standby application; 2, performing an addition reaction to synthesize o-methylphenyl-thiourea; 3, performing a ring-closure reaction to synthesize 4-methyl-2-aminobenzothiazole hydrochloride; 4, performing a substitution reaction to synthesize the 4-methyl-2-hydrazinobenzothiazole; and 5, performing drying and performing packaging.