38338-21-5

Basic information

• Product Name: 2-Benzothiazolamine,6-chloro-4-methyl-(9CI)
• Synonyms: 2-Benzothiazolamine,6-chloro-4-methyl-(9CI);6-chloro-4-methyl-1,3-benzothiazol-2-amine(SALTDATA: FREE);6-Chloro-4-Methyl-2-benzothiazolaMine;2-Amino-6-chloro-4-methylbenzothiazole
• CAS NO: 38338-21-5
• Molecular Formula: C₈H₇ClN₂S
• Molecular Weight: 198.676
• Product Categories: BENZOTHIAZOLE
• Mol File: 38338-21-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 206 °C
• Boiling Point: 360.3°C at 760 mmHg
• Flash Point: 171.7°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 2.24E-05mmHg at 25°C
• Refractive Index: 1.728
• PKA: 3.85±0.10(Predicted)
• CAS DataBase Reference: 2-Benzothiazolamine,6-chloro-4-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolamine,6-chloro-4-methyl-(9CI)(38338-21-5)
• EPA Substance Registry System: 2-Benzothiazolamine,6-chloro-4-methyl-(9CI)(38338-21-5)

Safety Data

• Hazardous Substances Data: 38338-21-5(Hazardous Substances Data)

Usage

General Description

2-Benzothiazolamine,6-chloro-4-methyl-(9CI) is a chemical compound that belongs to the class of benzothiazoles. It is an organic compound with the molecular formula C9H7ClNS and a molecular weight of 203.68 g/mol. This chemical is a chloro-substituted derivative of 2-benzothiazolamine and contains a chlorine atom and a methyl group attached to the benzothiazole ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals, and it may also have other industrial applications. 2-Benzothiazolamine,6-chloro-4-methyl-(9CI) is a yellowish crystalline solid with a melting point of around 97-99°C and is sparingly soluble in water but soluble in organic solvents. As with all chemicals, proper handling and storage procedures should be followed to ensure safety and prevent any potential hazards.

InChI:InChI=1/C8H7ClN2S/c1-4-2-5(9)3-6-7(4)11-8(10)12-6/h2-3H,1H3,(H2,10,11)

Upstream product

• 614-78-8 o-tolylthiourea 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 333-20-0 potassium thioacyanate 
• 56-23-5 tetrachloromethane 
• 63980-71-2 N-(4-Chloro-2-methylphenyl)thiourea 
• 7782-50-5 chlorine 
• 108-90-7 chlorobenzene 
• 7791-25-5 sulfuryl dichloride 
• 540-72-7 sodium thiocyanide 
• 64036-72-2 4-methyl-2-aminobenzothiazole hydrochloride 

Downstream Products

• 1242168-43-9 C₂₁H₁₆Cl₂N₂OS 
• 90006-61-4 4-chloro-2-methyl-6-(methylthio)aniline 
• 101326-14-1 2-amino-5-chloro-3-methyl-thiophenol 

Relevant articles and documents

Synthesis and insecticidal evaluation of novel sulfide-containing amide derivatives as potential ryanodine receptor modulators

With the aim of discovering new bioactive pesticides for crop protection, a series of novel sulfide-containing amide derivatives A were efficiently synthesized via a strategy of modifying the “amide” structure of anthranilic diamide insecticides. The single-crystal structures of A2-3 and A4-5 were firstly reported. The bioassay results showed that most of the synthesized compounds display moderate to high insecticidal activities. Particularly, some sulfone-containing compounds, e.g., A2-3, A3-3 and A6-3, not only possessed favorable lethality rate (50%–100%) against P. xylostella at a concentration of 0.1 mg/L, but also held good activities towards a variety of agricultural pests such as M. separata, C. pipiens pallen, H. armigera and O. nubilalis; the larvicidal activities of A4-1 and A6-1 towards P. xylostella were close to that of chlorantraniliprole at 0.01 mg/L. The calcium imaging experiments revealed that the representative compounds A2-3 and A6-3 are potential ryanodine receptor (RyR) modulators. The structure–activity relationships were discussed in detail. These results provide useful information for further design and development of novel insecticides.

Synthesis and biological evaluation of novel N-pyridylpyrazolecarboxamides containing benzothiazole

A series of novel N-pyridylpyrazolecarboxamides containing benzothiazolewere designed and synthesized. The target compounds were identified by 1H NMR,13C-NMR, IR, high-resolution mass spectrum (HRMS) and elemental analysis. The bioactivities of the newcom