38338-21-5Relevant academic research and scientific papers
Synthesis and insecticidal evaluation of novel sulfide-containing amide derivatives as potential ryanodine receptor modulators
Zhang, Yan,Li, Yuxin,Li, Huan,Shang, Junfeng,Li, Zhengming,Wang, Baolei
supporting information, p. 501 - 507 (2021/06/15)
With the aim of discovering new bioactive pesticides for crop protection, a series of novel sulfide-containing amide derivatives A were efficiently synthesized via a strategy of modifying the “amide” structure of anthranilic diamide insecticides. The single-crystal structures of A2-3 and A4-5 were firstly reported. The bioassay results showed that most of the synthesized compounds display moderate to high insecticidal activities. Particularly, some sulfone-containing compounds, e.g., A2-3, A3-3 and A6-3, not only possessed favorable lethality rate (50%–100%) against P. xylostella at a concentration of 0.1 mg/L, but also held good activities towards a variety of agricultural pests such as M. separata, C. pipiens pallen, H. armigera and O. nubilalis; the larvicidal activities of A4-1 and A6-1 towards P. xylostella were close to that of chlorantraniliprole at 0.01 mg/L. The calcium imaging experiments revealed that the representative compounds A2-3 and A6-3 are potential ryanodine receptor (RyR) modulators. The structure–activity relationships were discussed in detail. These results provide useful information for further design and development of novel insecticides.
Pyrazolecarboxamide derivative containing substituted sulfoximine acyl aryl as well as preparation method and application thereof
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Paragraph 0046; 0051-0054, (2020/06/16)
The invention relates to a pyrazolecarboxamide derivative containing substituted sulfoximine acyl aryl as well as a preparation method and application thereof. On the basis of a sulfur-containing substituted arylamine intermediate, a compound obtained through a series of reactions is shown as a general formula I in the specification. The compound shown in the general formula I has good insecticidal activity, is especially effective to oriental armyworms and plutella xylostella, can be used as an active component of an insecticidal composition, is used for preparing agricultural insecticides, and is used for preventing and treating agricultural insect pests.
Synthesis and biological evaluation of novel N-pyridylpyrazolecarboxamides containing benzothiazole
Mao, Ming-Zhen,Wang, Hai-Yang,Wang, Wei,Ning, Bin-Ke,Li, Yu-Xin,Xiong, Li-Xia,Li, Zheng-Ming
, p. 42 - 46 (2016/12/24)
A series of novel N-pyridylpyrazolecarboxamides containing benzothiazolewere designed and synthesized. The target compounds were identified by 1H NMR,13C-NMR, IR, high-resolution mass spectrum (HRMS) and elemental analysis. The bioactivities of the newcom
