640721-04-6

Basic information

• Product Name: (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate
• Synonyms: (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate
• CAS NO: 640721-04-6
• Molecular Weight: 480.225
• Mol File: 640721-04-6.mol

Chemical Properties

• CAS DataBase Reference: (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate(640721-04-6)
• EPA Substance Registry System: (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate(640721-04-6)

Safety Data

• Hazardous Substances Data: 640721-04-6(Hazardous Substances Data)

Upstream product

• 640721-05-7 3-O-[[[6-bromo-7-(methoxymethoxy)coumarin-4-yl]methoxy]carbonyl]-1,2-di-O-octanoylglycerol 
• 640721-06-8 3-O-[[(6-bromo-7-hydroxycoumarin-4-yl)methoxy]carbonyl]-1,2-di-O-octanoylglycerol 
• 640721-03-5 [[6-bromo-7-(methoxymethoxy)coumarin-4-yl]methoxy]carbonyl chloride 
• 223420-41-5 6-bnromo-7-hydroxy-4-(hydroxymethyl)-2H-chromen-2-one 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 640721-02-4 6-bromo-4-hydroxymethyl-7-(methoxymethoxy)-2H-chromen-2-one 

Downstream Products

• 1395061-53-6 C₈₉H₁₁₅BrN₁₀O₄₀ 
• 1395061-51-4 C₄₃H₅₃BrN₄O₂₀ 

Relevant articles and documents

Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation

The site-specific incorporation of three new coumarin lysine analogues into proteins was achieved in bacterial and mammalian cells using an engineered pyrrolysyl-tRNA synthetase system. The genetically encoded coumarin lysines were successfully applied as

Photocontrolled compound release system using caged antimicrobial peptide

A novel photocontrolled compound release system using liposomes and a caged antimicrobial peptide was developed. The caged antimicrobial peptide was activated by UV irradiation, resulting in the formation of pores on the liposome surface to release the contained fluorophores. The compound release could be observed using fluorescence measurements and time-lapse fluorescence microscopy. UV irradiation resulted in a quick release of the inclusion compounds (within 1 min in most cases) under simulated physiological conditions. The proposed system is expected to be applicable in a wide range of fields from cell biology to clinical sciences.

Coumarin-4-ylmethoxycarbonyls as Phototriggers for Alcohols and Phenols

(Equation Presented) Caged compounds can be used to regulate the spatial and temporal dynamics of signaling molecules in live cells. Photochemical properties of coumarin-4-ylmethoxy carbonates (1a-d) are investigated to construct caged compounds of hydroxy-containing molecules. All the compounds possess desired properties as phototriggers for alcohols and phenols. The 6-bromo-7-hydroxycoumarin-4-ylmethoxycarbonyl (Bhcmoc) group has the highest photochemical efficiency and is applied to make caged compounds of 1,2-dioctanoylglycerol (diC8), Tyr-OMe, and adenosine.