640722-73-2

Upstream product

• 19255-60-8 (E)-4,4-dimethoxy-but-2-enoic acid ethyl ester 
• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 640722-78-7 1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)-piperidine-2,6-dione 

Downstream Products

• 808141-10-8 1-benzyl-4-dimethoxymethyl-3-(2-chloroallyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-13-1 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-16-4 1-benzyl-3-(4-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-19-7 1-benzyl-4-dimethoxymethyl-3-(3-methoxybenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-50-6 2-benzyl-7-bromo-3,4-dihydro-2H-benzo[g]isoquinolin-1-one 
• 808141-35-7 1-benzyl-3-(4-methylbenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde 
• 808141-38-0 1-benzyl-3-(4-bromobenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde 
• 808141-36-8 1-benzyl-3-(2-bromobenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde 
• 808141-39-1 1-benzyl-3-(2-methoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde 
• 808141-41-5 1-benzyl-3-(4-methoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde 
• 808141-15-3 1-benzyl-3-(2-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-08-4 1-benzyl-4-dimethoxymethyl-3-(2-methylallyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-21-1 1-benzyl-4-dimethoxymethyl-3-(4-methoxy-benzyl)-3-(toluene-4-sulfonyl)-piperidin-2-one 
• 808141-12-0 1,3-dibenzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 

Relevant academic research and scientific papers

Regioselective reduction of N-alkyl-3-sulfonyl glutarimides to δ-lactams. Formal synthesis of (±)-paroxetine and (±)-tacamonine

A convenient method for the preparation of 4- or 5-substituted 3-sulfonyl-δ-lactams via regioselective reduction of N-alkyl-3-sulfonyl glutarimides is described. Formal synthesis of (±)-paroxetine and (±)-tacamonine is also reported.

Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones skeleton via intramolecular electrophilic cyclization

An original alternative approach to isoquinolines based on the installation of a benzene nucleus on a performed heterocyclic ring. Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)- ones via intramolecular electrophilic cyclization of 3,4-disubstituted lactams is reported. Graphical Abstract.