19255-60-8

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 51673-84-8 dimethoxyacetaldehyde 
• 64-17-5 ethanol 
• 18778-96-6 (2E)-4,4-dimethoxybut-2-enal 

Downstream Products

• 52466-61-2 6-Dimethoxymethyl-4-ethoxy-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester 
• 640722-73-2 1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-08-4 1-benzyl-4-dimethoxymethyl-3-(2-methylallyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-17-5 1-benzyl-4-dimethoxymethyl-3-thiophen-2-ylmethyl-3-(toluene-4-sulfonyl)-piperidin-2-one 
• 808141-16-4 1-benzyl-3-(4-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-15-3 1-benzyl-3-(2-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-13-1 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-20-0 4-[1-benzyl-4-dimethoxymethyl-2-oxo-3-(toluene-4-sulfonyl)piperidin-3-ylmethyl]benzoic acid methyl ester 
• 808141-23-3 1-benzyl-3-(3,4-dimethoxybenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 1150567-97-7 (6-phenethyl-imidazo[1,2-b]pyridazin-3-yl)-acetic acid 
• 7328-34-9 ethyl 2E,4E-decadienoate 
• 3025-30-7 ethyl (2E,4Z)-2,4-decadienoate 
• 101820-69-3 imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester 
• 2960-66-9 4-oxo-but-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Organocatalyzed Michael-Henry reactions: Enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

HEMATOPOIETIC NEOPLASM CHEMOTHERAPY

A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproliferative disorder, or non-MLL based acute lymphoid leukemia is provided.

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protei kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

Stereoselective synthesis of methyl and ethyl (2E,4Z)-2,4-decadienoates from (E)-4,4-dimethoxy-2-butenal

Methyl and ethyl (2E,4Z)-2,4-decadienoates were synthesized starting from (E)-4,4-dimethoxy-2-butenal.

SYNTHESE STEREOSELECTIVE DU DECADIENE-2(E), 4(Z)OATE D'ETHYLE. A PARTIR D'UN MONOACETAL DU GLYOXAL

The glyoxal monoacetal 2, now readily available in bulk quantity, is a very useful synthon for the dienes-1,3 synthesis, as illustrated in the stereoselective preparation of ethyl 2E,4Z-decadienoate using two Wittig-type olefination reactions.