64075-36-1

Upstream product

• 107-10-8 propylamine 
• 101-94-0 p-tolyl phenylacetate 
• 103-80-0 phenylacetyl chloride 
• 1239867-58-3 3-methylbut-2-enyl 2-phenyl-N-propylacetimidate 
• 201230-82-2 carbon monoxide 
• 108-88-3 toluene 
• 122-78-1 phenylacetaldehyde 
• 71-23-8 propan-1-ol 
• 103-81-1 Benzeneacetamide 
• 101-41-7 benzeneacetic acid methyl ester 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 176438-06-5 N-propyl-3-hydroxy-2-phenylprop-2-enamide 

Relevant academic research and scientific papers

Thoination of N-alkyl-O-acyl hydroxamic acid derivatives via Lawesson's reagent

N-alkyl-O-acyl thiohydroxamic acid derivatives were prepared in good yields by the treatment of their parent hydroxamic acids with Lawesson's reagent. Some of these thiohydroxamic acid derivatives exhibit the ability to undergo rearrangement under basic c

Selective C-N σ bond cleavage in azetidinyl amides under transition metal-free conditions

Functionalization of amide bond via the cleavage of a non-carbonyl, C-N σ bond remains under-investigated. In this work, a transition-metal-free single-electron transfer reaction has been developed for the C-N σ bond cleavage of N-acylazetidines using the

Method for synthesizing N-n-propylamide

The invention belongs to the field of organic synthesis, and relates to a novel reaction method for selectively breaking a C-Nsigma bond in azacyclobutanamide and converting the bond into N-n-propylamide. According to the method, an azacyclobutanamide-bas

Solvent-Free N-Alkylation of Amides with Alcohols Catalyzed by Nickel on Silica–Alumina

The N-alkylation of phenylacetamide with benzyl alcohol has been studied using Ni/SiO2–Al2O3. In the optimized conditions, the desired product was isolated in an excellent 98 % yield. The reaction could advantageously be performed in neat conditions, with a slight excess of amide and a catalytic amount of base. These conditions were tested on a large range of amides and alcohols, affording 24 compounds in 13 to 99 % isolated yields.

Catalyst-free amidation of aldehyde with amine under mild conditions

A highly efficient, catalyst-free and one-pot procedure for the direct synthesis of amides from aldehydes and amines under mild conditions has been developed. Both aliphatic and aromatic aldehydes with primary or secondary amines are successfully converted to the corresponding amides, and it is observed that reactions can proceed in either aqueous or organic media.

Ammonium nitrate: A biodegradable and efficient catalyst for the direct amidation of esters under solvent-free conditions

A simple, metal-free, and environment-friendly procedure is developed for the direct conversion of esters to amides using ammonium nitrate as a catalyst under solvent-free conditions. Aryls, heteroaryls, and aliphatic esters are easily converted to the corresponding amides in excellent isolated yields (85-99%). An enantiopure ester and amine were both shown to react without racemization. The methodology has been successfully applied to preparation of procainamide.

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Carboxyl activation of 3-mercapto-5,6-diphenyl-1,2,4-triazine through N-phenylacetyl-5,6-diphenyl-1,2,4-triazine-3-thione

The carboxyl activation ability of 3-mercapto-5,6-diphenyl-1,2,4-triazine has been established by coverting it into N-phenylacetyl-5,6-diphenyl-1,2,4-triazine-3-thione and this was then subjected to aminolysis and esterification with amines and alcohols respectively and selective aminolysis with aminoalcohols-monitoring chemically and confirmed spectrophotometrically by UV-Visible scannings. It could be proved that 3- mercapto-5,6-diphenyl-1,2,4-triazine is an efficient carboxyl activating group which can be successfully applied in solid phase peptide synthesis.

Palladium-catalyzed oxidative aminocarbonylation: A new entry to amides via C-H activation

A novel palladium-catalyzed oxidative aminocarbonylation reaction via C(sp3)-H activation was established, which provides a convenient and general method for the construction of arylacetamides via the carbonylation reaction of alkyl aromatics and amines. By using this protocol, the marketed drug ibuprofen could be easily obtained.

An efficient protocol for the preparation of amides by copper-catalyzed reactions between nitriles and amines in water

The reactions between nitriles and amines catalyzed by Cu(OAc)2 and 2-piperidinecarboxylic acid were carried out in pure water without any other additives. A variety of substituted amides can be obtained in moderate to good yields up to 90%.