64096-86-2Relevant academic research and scientific papers
NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR
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Page/Page column 5-6, (2020/12/30)
The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.
METHOD FOR PRODUCING 1,1-DIOXO-HEXAHYDRO-THIOPYRAN-4-CARBOXYLIC ACID OR DERIVATIVE THEREOF
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Paragraph 0069; 0074, (2018/06/05)
PROBLEM TO BE SOLVED: To provide a practical and efficient method for producing 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid or a derivative thereof in an industrial scale. SOLUTION: Provided ia a method for producing 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid represented by the following formula or a derivative thereof, comprising: (step 1) a step of mesylating two hydroxy groups of di(2-hydroxyethyl) sulfone; (step 2) a step of condensing the dimesylated body with meldrum acid to obtain 3,3-dimethyl-9,9-dioxo-2,4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione; and (step 3) a step of hydrolyzing and decarbonating the aforementioned compound to obtain 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
A practical, efficient synthesis of 1,1-dioxo-hexahydro-1#-thiopyran-4- carbaldehyde
Bio, Matthew M.,Hansen, Karl B.,Gipson, John
, p. 892 - 895 (2013/01/03)
A practical, efficient, and scalable procedure for the preparation of l,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde is reported. Synthesis of this aldehyde was complicated by high aqueous solubility of the product and the intermediates. The isolation and purification of the aldehyde was accomplished by conversion to the crystalline bisulfite adduct.
