841301-32-4

Basic information

• Product Name: ASP 2151
• Synonyms: ASP 2151;AMenaMevir;N-(2,6-Dimethylphenyl)tetrahydro-N-[2-[[4-(1,2,4-oxadiazol-3-yl)phenyl]amino]-2-oxoethyl]-2H-thiopyran-4-carboxamide 1,1-dioxide
• CAS NO: 841301-32-4
• Molecular Formula: C24H26N4O5S
• Molecular Weight: 482.55204
• Mol File: 841301-32-4.mol

Chemical Properties

• Appearance: /
• Density: 1.360±0.06 g/cm3(Predicted)
• PKA: 12.60±0.70(Predicted)
• CAS DataBase Reference: ASP 2151(CAS DataBase Reference)
• NIST Chemistry Reference: ASP 2151(841301-32-4)
• EPA Substance Registry System: ASP 2151(841301-32-4)

Safety Data

• Hazardous Substances Data: 841301-32-4(Hazardous Substances Data)

Usage

Uses

Used in Antiviral Therapy:
ASP 2151 is used as an antiviral agent for the treatment of infections caused by herpes simplex viruses (HSV-1 and HSV-2) and varicella-zoster virus (VZV). It exhibits inhibitory effects on the replication of these viruses in human embryonic fibroblast (HEF) cells, with EC50 values of 0.047, 0.036, and 0.028 μM for VZV, HSV-1, and HSV-2, respectively. Additionally, it has shown to increase the survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection, with an ED50 of 1.9 mg/kg twice per day.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ASP 2151 is used as a key component in the development of antiviral drugs targeting herpes simplex viruses and varicella-zoster virus. Its potent antiviral activity and low cytotoxicity make it a promising candidate for the treatment of viral infections caused by these viruses.

Upstream product

• 619-72-7 4-nitrobenzonitrile 
• 50-00-0 formaldehyd 
• 87-62-7 2,6-dimethylaniline 
• 64096-87-3 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid 
• 64096-86-2 3,3-dimethyl-2,4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione-9,9-dioxide 
• 1613-86-1 N-hydroxy-4-nitrobenzamidine 
• 16013-14-2 3-(4-nitrophenyl)-[1,2,4]oxadiazole 
• 59908-70-2 4-[1,2,4]oxadiazol-3-yl-phenylamine 

Relevant articles and documents

NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR

The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.

Preparation method of amenamevir and intermediate thereof

The invention discloses a preparation method of amenamevir and an intermediate thereof. The invention provides a preparation method of a compound as shown in a formula (V). The preparation method comprises the following steps: adding a compound as shown i

AMIDO DERIVATIVES-CONTAINED PHARMACEUTICAL COMPOSITION

The present invention relates to a pharmaceutical composition containing a solid dispersion comprising an amide derivative or a salt thereof and a water-soluble polymer, wherein the pharmaceutical composition is not prepared by a melting method. The pharmaceutical composition contains the solid dispersion having an improved oral absorption, properties suitable for formulation, and an excellent stability.

THERAPEUTIC AGENT FOR HERPES PROGENITALIS

[PROBLEMS] To provide a medicament useful for the treatment of genital herpes after the development of lesions. [MEANS FOR SOLVING PROBLEMS] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phe

AGENT FOR PREVENTION/TREATMENT OF DISEASE CAUSED BY ACYCLOVIR-RESISTANT HERPESVIRUS

[PROBLEMS] To provide an agent useful for the prevention or treatment of various diseases associated with the infection with acyclovir-resistant viruses of the family Herpesviridae, specifically various infectious caused by herpesviruses, such as varicell

PREVENTIVE OR THERAPEUTIC AGENT FOR HERPESVIRUS-RELATED DISEASE

[PROBLEMS] To provide a medicament, particularly a pharmaceutical composition useful for preventing or treating a variety of diseases caused by infection of a virus of the Herpesviridae family. [MEANS FOR SOLVING PROBLEMS] The present invention relates to

Tetrahydro-2H-thiopyran-4-carboxamide derivative

A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chic