64141-90-8

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-N-ISOPROPYLBENZAMIDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs.
Used in Agrochemical Industry:
2-BROMO-N-ISOPROPYLBENZAMIDE is used as an intermediate in the synthesis of agrochemicals to help create effective products for agricultural applications.
Used in Medicinal Chemistry:
2-BROMO-N-ISOPROPYLBENZAMIDE is used as an anti-inflammatory and analgesic agent due to its potential therapeutic properties in reducing inflammation and pain.
Used in Organic Synthesis:
2-BROMO-N-ISOPROPYLBENZAMIDE is used as a building block in organic synthesis for the preparation of various heterocyclic compounds, which are important in the creation of diverse chemical products.

InChI:InChI=1/C10H12BrNO/c1-7(2)12-10(13)8-5-3-4-6-9(8)11/h3-7H,1-2H3,(H,12,13)

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 75-31-0 isopropylamine 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 2042-37-7 o-cyanobromobenzene 

Relevant academic research and scientific papers

Tailoring buchwald-type phosphines with pyrimidinium betaines as versatile aryl group surrogates

A derivatization of dialkylbiarylphosphines consisting in the formal replacement of their distal aryl group by a pyrimidinium betaine is reported. Two achiral representatives of this new class of Buchwald-type phosphines have been successfully synthesized through two strategies. The first one is based on a last stage introduction of the phosphino moiety, and the second one consists in a modular, one-pot, three-step procedure starting from an o-bromoaryl phosphine. The resulting phosphines have been coordinated onto gold(I) and palladium(II) centers and have been employed as supporting ligands in Pd-catalyzed Suzuki-Miyaura cross-coupling of aryl halide substrates.

Does Formal Intramolecular Transfer of an Acidic Deuterium to a Site of Halogen-Lithium Exchange Show That Lithium-Halogen Exchange Is Faster than Loss of the Acidic Deuterium? Evidence in Favor of an Alternative Mechanism

Reactions in which there is formal intramolecular transfer of an acidic deuterium to a site of halogen-lithium exchange could be interpreted to show that initial halogen-lithium exchange occurs faster than loss of the acidic deuterium.However studies of the competition between halogen-metal-deuterium exchange and deuterium loss for N-deuterio-N-alkyl-o, -m, and -p-halobenzimides are not consistent with that mechanism.We suggest an alternative in which initial loss of the acidic deuterium is followed by halogen-lithium exchange to give a dilithiated intermediate.Deuterium transfer to the site of halogen-lithium exchange then occurs by reaction of the dilithiated species intermolecularly with unreacted N-deuteriated amide.The halogen-lithium exchange is faster than complete mixing of the reactants and can occur either in an initially formed deprotonated complex or in a transient high local concentration of organolithium reagent.Evidence for both possibilities is provided.Two reactions from the literature in which halogen-lithium exchange appears to be faster than transfer of an acidic hydrogen have been reinvestigated and found to be interpretable in terms of similar sequences.