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Diisopropyl phosphoramidite is a chemical compound with the formula (iPrO)2P(O)NR2, where R represents an alkyl or aryl group. It is widely used in organic synthesis, particularly in the formation of phosphite esters and as a coupling agent in the synthesis of oligonucleotides and other nucleic acid derivatives. This reagent is known for its stability and high reactivity, which makes it a popular choice in various chemical reactions. It is also used in the preparation of phosphorus-containing compounds and as a ligand in transition metal catalysis. The compound is typically handled with care due to its potential reactivity and toxicity.

6415-20-9

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6415-20-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6415-20-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,1 and 5 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6415-20:
(6*6)+(5*4)+(4*1)+(3*5)+(2*2)+(1*0)=79
79 % 10 = 9
So 6415-20-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H16NO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3,(H2,7,8)

6415-20-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Diisopropyl phosphoramidite

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:6415-20-9 SDS

6415-20-9Relevant academic research and scientific papers

Spontaneous Lossen Rearrangement of (Phosphonoformyl)hydroxamates. The Migratory Aptitude of the Phosphonyl Group

Salomon, Claudio J.,Breuer, Eli

, p. 3858 - 3861 (2007/10/03)

(i-PrO)2P(=O)COSEt (1) reacted with NH2OH in pyridine at room temperature to give mainly (i-PrO)2P(=O)NH2 (4). The formation of 4 was interpreted in terms of a spontaneous Lossen rearrangement of (i-PrO)2P(=O)CONHOH (2a) formed in the reaction. A transient 31P NMR signal appearing in the reaction mixture at δ-1.8 was assigned to 2a. Trapping of (i-PrO)2P(=O)N=C=O (5), formed in the reaction of 1 and NH2OH, by cyclohexylamine gave (i-PrO)2P(=O)NHCONHC6H11 (6). Attempted isolation of 6 gave the hydrolyzed product N-cyclohexylurea (7). The reaction of 1 with NH2OMe proceeded slower than that with NH2OH and gave the expected (i-PrO)2P(=O)-CONHOMe (2b), which was isolated and identified. 2b converts slowly to 4 in pyridine at room temperature. In contrast, MeNHOH reacted rapidly with 1 and gave the stable crystalline (i-PrO)2P(=O)CON(Me)OH (2c). The structure of hydroxamates 2 were assigned on the basis of 1H, 13C, and 31P NMR spectral data. This facile Lossen rearrangement is discussed in terms of the unusually high migratory aptitude of the phosphonyl group.

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