diisopropyl phosphoramidite

Base Information

• Chemical Name: diisopropyl phosphoramidite
• CAS No.: 6415-20-9
• Molecular Formula: C6H16 N O3 P
• Molecular Weight: 181.172
• Hs Code.: 2929909090
• Mol file: 6415-20-9.mol

Synonyms:Isopropylphosphoramidate (6CI,7CI); Phosphoramidic acid, diisopropyl ester (8CI);Diisopropoxyphosphorylamide; Diisopropyl amidophosphonate; Diisopropylphosphoramidate

Chemical Property of diisopropyl phosphoramidite

Chemical Property:

• Vapor Pressure: 0.000441mmHg at 25°C
• Boiling Point: 315.3°C at 760 mmHg
• Flash Point: 144.5°C
• PSA: 71.36000
• Density: 1.072g/cm³
• LogP: 2.60350

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diisopropyl phosphoramidite

There total 3 articles about diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) + diisopropyl ethyl phosphonothiolformate (163678-86-2) → diisopropyl hydrogenphosphonate (1809-20-7) + phosphoramidic acid diisopropyl ester (6415-20-9) + diisopropoxyphosphinylformylhydroxamic acid + C13H27N2O4P

Guidance literature:

With hydroxylamine hydrochloride; In pyridine; at 25 ℃; for 3h; Yields of byproduct given;

DOI:10.1021/jo962075k

Reference yield:

diisopropyl ethyl phosphonothiolformate (163678-86-2) → diisopropyl hydrogenphosphonate (1809-20-7) + phosphoramidic acid diisopropyl ester (6415-20-9) + diisopropoxyphosphinylformylhydroxamic acid

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In acetonitrile; at 25 ℃; for 2h; Product distribution; various reaction conditions;

DOI:10.1021/jo962075k

Reference yield:

tetrachloromethane (56-23-5) + diisopropyl hydrogenphosphonate (1809-20-7) + ammonia (7664-41-7) → phosphoramidic acid diisopropyl ester (6415-20-9) + chloroform (67-66-3,8013-54-5)

Guidance literature:

DOI:10.1039/jr9450000660

upstream raw materials:

cyclohexylamine

diisopropyl ethyl phosphonothiolformate

tetrachloromethane

diisopropyl hydrogenphosphonate

Downstream raw materials:

Diethyl phosphoramidate

diisopropyl N-sulfinylphosphoramidate

C₁₀H₂₆N₂O₈P₂S

C₁₂H₃₀N₂O₈P₂S

Refernces