641634-57-3

Upstream product

• 513-38-2 Isobutyl iodide 
• 641634-56-2 (S)-4-((benzyloxy)methyl)-1-((S)-1-phenylethyl)pyrrolidin-2-one 
• 188641-35-2 (4S,1'S)-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 641634-58-4 (3S,4S,1'S)-4-benzyloxymethyl-3-(2''-methylprop-1''-yl)-1-(1'-phenylethyl)pyrrolidine 
• 641634-59-5 (3S,4S)-3-benzyloxymethyl-1-(tert-butoxycarbonyl)-4-(2'-methylprop-1'-yl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of a conformationally restricted analog of pregabalin by stereoselective alkylation of a chiral pyrrolidin-2-one

The 4-benzyloxymethyl pyrrolidin-2-one, 5, was alkylated leading to 3,4-trans-disubstituted pyrrolidin-2-one 6 in good yield and total diastereoselection, as shown by 1H NMR data and NOE experiments. After reduction of the carbonyl group to giv