641634-56-2Relevant articles and documents
Synthesis of a conformationally restricted analog of pregabalin by stereoselective alkylation of a chiral pyrrolidin-2-one
Galeazzi, Roberta,Martelli, Gianluca,Mobbili, Giovanna,Orena, Mario,Rinaldi, Samuele
, p. 3353 - 3358 (2003)
The 4-benzyloxymethyl pyrrolidin-2-one, 5, was alkylated leading to 3,4-trans-disubstituted pyrrolidin-2-one 6 in good yield and total diastereoselection, as shown by 1H NMR data and NOE experiments. After reduction of the carbonyl group to giv