6418-00-4

Basic information

• Product Name: N-hydroxy-3-nitroaniline
• Synonyms: Benzenamine, N-hydroxy-3-nitro-; N-Hydroxy-3-nitrobenzenamine
• CAS NO: 6418-00-4
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.1234
• Mol File: 6418-00-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 301.4°C at 760 mmHg
• Flash Point: 136.1°C
• Density: 1.514g/cm³
• Vapor Pressure: 0.000467mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: N-hydroxy-3-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxy-3-nitroaniline(6418-00-4)
• EPA Substance Registry System: N-hydroxy-3-nitroaniline(6418-00-4)

Safety Data

• Hazardous Substances Data: 6418-00-4(Hazardous Substances Data)

Upstream product

• 99-65-0 meta-dinitrobenzene 
• 70-18-8 GLUTATHIONE 
• 142640-33-3 C₁₆H₂₁N₅O₉S 
• 64-17-5 ethanol 
• 99-09-2 3-nitro-aniline 
• 64-19-7 acetic acid 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 1230-85-9 3,3'-dinitro azoxybenzene 
• 122364-74-3 N-m-nitrophenyl-2-furylacrylohydroxamic acid 
• 3585-98-6 α-(4-(dimethylamino)phenyl)-N-(3-nitrophenyl)nitrone 
• 127089-95-6 N-Hydroxy-N-(3-nitro-phenyl)-formamide 
• 51639-69-1 N-3'-nitrophenyl-N-hydroxy-2-furancarboxamide 
• 17122-21-3 1-nitro-3-nitrosobenzene 
• 96127-03-6 N-Hydroxy-N-(3-nitro-phenyl)-benzamide 
• 119-34-6 4-amino-2-nitrophenol 

Relevant articles and documents

Polystyrene stabilized iridium nanoparticles catalyzed chemo- and regio-selective semi-hydrogenation of nitroarenes to N-arylhydroxylamines

Polystyrene stabilized Iridium (Ir@PS) nanoparticles (NPs) as a heterogeneous catalyst have been developed and characterized by IR, UV–Vis, SEM, TEM, EDX and XRD studies. The prepared Ir@PS catalyst showed excellent reactivity for chemo- and regio-selective controlled-hydrogenation of functionalized nitroarenes to corresponding N-arylhydroxylamine using hydrazine hydrate as reducing source and environmentally benign polyethylene glycol (PEG-400) as green solvent. The present methodology was applied for vast substrate scope and found to be compatible with wide range of reducible functional groups. The reaction performed at 85 °C or ambient temperature and completed within 5–80 minutes. The catalyst can easily be filtered out from reaction mixture and reusable.

Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1

A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.

Carbon supported Pt colloid as effective catalyst for selective hydrogenation of nitroarenes to arylhydroxylamines

The Pt colloid supported on carbon is an active and selective catalyst for the partial hydrogenation of nitroaromatics with electron-withdrawing substituents to the corresponding N-arylhydroxylamine, indicating an additive-free green catalytic approach fo