642016-99-7Relevant articles and documents
Four-Component Synthesis of 2-Amino-3-Cyanopyridine Derivatives Catalyzed by Cu@imineZCMNPs as a Novel, Efficient and Simple Nanocatalyst Under Solvent-Free Conditions
Yahyazadeh, Asieh,Abbaspour-Gilandeh, Esmayeel,Aghaei-Hashjin, Mehraneh
, p. 1254 - 1262 (2018)
Abstract: An efficient and convenient method was investigated for synthesis of 2-amino-3-cyanopyridine derivatives via a one-pot four-component reaction of various types of aldehydes, acetophenone, malononitrile, and ammonium acetate in the presence of 10
Unveiling the urease like intrinsic catalytic activities of two dinuclear nickel complexes towards thein situsyntheses of aminocyanopyridines
Kundu, Bidyut Kumar,Pragti,Biswas, Soumen,Mondal, Abhijit,Mazumdar, Shyamalava,Mobin, Shaikh M.,Mukhopadhyay, Suman
, p. 4848 - 4858 (2021/04/22)
Designing metal complexes as functional models for metalloenzymes remains one of the main targets in synthetic bioinorganic chemistry. Furthermore, the utilization of the product(s) derived from the catalytic reaction for subsequent organic transformation
Synthesis, cytotoxic assessment, and molecular docking studies of 2,6-diaryl-substituted pyridine and 3,4-dihydropyrimidine-2(1H)-one scaffolds
Aghahosseini, Hamideh,Hosseinzadeh, Zahra,Ramazani, Ali,Razzaghi-Asl, Nima
, p. 194 - 213 (2020/03/24)
Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytot
Boric acid as an efficient and green catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitrile under microwave irradiation in solvent-free conditions
Hosseinzadeh, Zahra,Lis, Tadeusz,Ramazani, Ali,Razzaghi-Asl, Nima,Slepokura, Katarzyna
, p. 464 - 474 (2021/05/06)
Microwave irradiation has been used to improve the one-pot synthesis of substituted 2-amino-4,6-diarylnicoti-nonitrile in the presence of boric acid as an efficient and green catalyst under solvent-free conditions within 48-60 s. All the analogs that have
Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3 catalyst for 2-amino-3-cyanopyridine preparation: Via an anomeric based oxidation
Zolfigol, Mohammad Ali,Kiafar, Mahya,Yarie, Meysam,Taherpour, Avat,Saeidi-Rad, Mahdi
, p. 50100 - 50111 (2016/06/15)
2-Amino-4,6-diphenylnicotinonitriles were prepared by using Fe3O4@SiO2@(CH2)3Im}C(CN)3 as a nanostructured catalyst with an ionic liquid tag under solvent free and benign conditions. Experimental evidence and theoretical studies confirmed that the final step of the synthetic pathway proceeded via an anomeric based oxidation mechanism. A good range of aromatic aldehydes were condensed with acetophenone derivatives, malononitrile and ammonium acetate to afford their corresponding products in short reaction times and good to high yields.
Divergent syntheses of 2-aminonicotinonitriles and pyrazolines by copper-catalyzed cyclization of oxime ester
Wu, Qifan,Zhang, Yan,Cui, Sunliang
supporting information, p. 1350 - 1353 (2014/04/03)
Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.