642087-18-1

Basic information

• Product Name: (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester
• Synonyms: (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester
• CAS NO: 642087-18-1
• Molecular Weight: 827.456
• Mol File: 642087-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester(642087-18-1)
• EPA Substance Registry System: (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester(642087-18-1)

Safety Data

• Hazardous Substances Data: 642087-18-1(Hazardous Substances Data)

Upstream product

• 642087-13-6 3-(diethoxyphosphinyl)-N-(3-chloro-4-methoxyphenyl)-D-alanine tert-butyl ester 
• 642087-19-2 2-[2-(diethoxy-phosphoryl)-acetylamino]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester 
• 642087-20-5 2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid benzyl ester 
• 642087-16-9 ethyl (3S,4R)-3-acetoxy-4-methyl-6-phenylhexan-(5E)-oate 
• 281190-95-2 (R)-tert-butyl 2-amino-3-(4-methoxyphenyl)propionate 
• 180181-02-6 3-(tert-Butoxycarbonyl)amino-2,2-dimethylpropanoic Acid 
• 186193-10-2 (2S)-<3-<<(1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoic acid 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 
• 642087-17-0 3-(3-chloro-4-methoxyphenyl)-(2R)-2-((5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2(E),7(E)-dienoylamino)propionic acid tert-butyl ester 

Downstream Products

• 186256-68-8 cryptophycin 53 
• 186256-67-7 cryptophycin 52 
• 186256-66-6 cryptophycin-51 
• 186193-12-4 (S)-2-(3-Amino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 

Relevant articles and documents

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A highly enantioselective and convergent synthesis of cryptophycin 52 (2), an exceedingly potent cytotoxic agent, is described. Cryptophycin 52, a synthetic variant of the cryptophycin family, is currently undergoing clinical trials. The synthesis is conv