642087-19-2

Upstream product

• 3095-95-2 diethylphosphonoacetic acid 
• 281190-95-2 (R)-tert-butyl 2-amino-3-(4-methoxyphenyl)propionate 

Downstream Products

• 642087-18-1 (2S)-2-(3-tert-butoxycarbonylamino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R,2E)-1-{3-[1-tert-butoxycarbonyl-(2R)-2-(3-chloro-4-methoxyphenyl)ethylcarbamoyl]allyl}-2-methyl-4-phenyl-but-(3E)-enyl ester 
• 186193-12-4 (S)-2-(3-Amino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 642087-17-0 3-(3-chloro-4-methoxyphenyl)-(2R)-2-((5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2(E),7(E)-dienoylamino)propionic acid tert-butyl ester 
• 186256-68-8 cryptophycin 53 
• 186256-67-7 cryptophycin 52 
• 186256-66-6 cryptophycin-51 
• 642087-13-6 3-(diethoxyphosphinyl)-N-(3-chloro-4-methoxyphenyl)-D-alanine tert-butyl ester 

Relevant academic research and scientific papers

Enantioselective Synthesis of (+)-Cryptophycin 52 (LY355703), a Potent Antimitotic Antitumor Agent

A highly enantioselective and convergent synthesis of cryptophycin 52 (2), an exceedingly potent cytotoxic agent, is described. Cryptophycin 52, a synthetic variant of the cryptophycin family, is currently undergoing clinical trials. The synthesis is conv