64222-33-9

Basic information

• Product Name: 2-Hydroxy-3-nitro-1,5-naphthyridine
• Synonyms: 2-Hydroxy-3-nitro-1,5-naphthyridine;3-Nitro-1,5-naphthyridin-2(1H)-one
• CAS NO: 64222-33-9
• Molecular Formula: C₈H₅N₃O₃
• Molecular Weight: 191.145
• Mol File: 64222-33-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 390.017 °C at 760 mmHg
• Flash Point: 189.676 °C
• Appearance: /
• Density: 1.54
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.744
• CAS DataBase Reference: 2-Hydroxy-3-nitro-1,5-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-nitro-1,5-naphthyridine(64222-33-9)
• EPA Substance Registry System: 2-Hydroxy-3-nitro-1,5-naphthyridine(64222-33-9)

Safety Data

• Hazardous Substances Data: 64222-33-9(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-3-nitro-1,5-naphthyridine is a chemical compound with the molecular formula C11H7N3O3. It is a derivative of naphthyridine and contains a hydroxy and nitro group. 2-Hydroxy-3-nitro-1,5-naphthyridine has potential applications in the pharmaceutical industry as it exhibits antimicrobial and anti-inflammatory properties. It has also been used as a precursor for the synthesis of various bioactive molecules. Additionally, 2-Hydroxy-3-nitro-1,5-naphthyridine has been studied for its potential use in the development of new drugs for the treatment of various diseases. Overall, this chemical compound holds promise for pharmaceutical and medicinal applications due to its unique molecular structure and potential biological activities.

InChI:InChI=1/C8H5N3O3/c12-8-7(11(13)14)4-6-5(10-8)2-1-3-9-6/h1-4H,(H,10,12)

Upstream product

• 38956-59-1 2-acetamido-1,5-naphthyridine 
• 33630-94-3 5-amino-2-hydroxypyridine 
• 10261-82-2 1,5-naphthyridin-2(1H)-one 

Downstream Products

• 14756-77-5 3-Amino-1,5-naphthyridin 

Relevant articles and documents

Methylamination of some 3-nitro-1,5-naphthyridines with liquid methylamine/potassium permanganate

3-Nitro-1,5-naphthyridine and its 2-substituted derivatives (1a-f) are dehydro-methylaminated with a solution of potassium permanganate in liquid methylamine (LMA-PP) to the corresponding 4-methylamino-3-nitro-1,5- naphthyridines (3a-e). The intermediary 4-methylamino σ adducts of 2-R-3-nitro-1,5-naphthyridines (R = H, NH2, Cl, NHCH3, OC2H5, OH) (2a-f) are detected by 1H nmr spectroscopy. The observed highly regioselective course of study reactions was confirmed by PM3 quantum chemical calculations of the reaction pathway. The calculations show satisfactory agreement between calculated and observed results. A convenient synthesis of 2-hydroxy- and 4-methylamino-3-nitro-1,5- naphthyridine are reported.