64222-33-9 Usage
Uses
Used in Pharmaceutical Industry:
2-Hydroxy-3-nitro-1,5-naphthyridine is used as an antimicrobial agent for its ability to combat various microorganisms, which is crucial in the development of new antibiotics to address the growing issue of antibiotic resistance.
2-Hydroxy-3-nitro-1,5-naphthyridine is also used as an anti-inflammatory agent, leveraging its capacity to reduce inflammation, which is essential in the treatment of various inflammatory conditions.
Used in Drug Development:
2-Hydroxy-3-nitro-1,5-naphthyridine is used as a precursor in the synthesis of bioactive molecules, contributing to the creation of new compounds with potential therapeutic applications.
Furthermore, 2-Hydroxy-3-nitro-1,5-naphthyridine is utilized in the research and development of new drugs, particularly for the treatment of various diseases, as its unique structure and properties offer opportunities for novel therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 64222-33-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,2,2 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 64222-33:
(7*6)+(6*4)+(5*2)+(4*2)+(3*2)+(2*3)+(1*3)=99
99 % 10 = 9
So 64222-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H5N3O3/c12-8-7(11(13)14)4-6-5(10-8)2-1-3-9-6/h1-4H,(H,10,12)
64222-33-9Relevant academic research and scientific papers
Methylamination of some 3-nitro-1,5-naphthyridines with liquid methylamine/potassium permanganate
Grzegozek, Maria,Szpakiewicz, Barbara
, p. 425 - 430 (2007/10/03)
3-Nitro-1,5-naphthyridine and its 2-substituted derivatives (1a-f) are dehydro-methylaminated with a solution of potassium permanganate in liquid methylamine (LMA-PP) to the corresponding 4-methylamino-3-nitro-1,5- naphthyridines (3a-e). The intermediary 4-methylamino σ adducts of 2-R-3-nitro-1,5-naphthyridines (R = H, NH2, Cl, NHCH3, OC2H5, OH) (2a-f) are detected by 1H nmr spectroscopy. The observed highly regioselective course of study reactions was confirmed by PM3 quantum chemical calculations of the reaction pathway. The calculations show satisfactory agreement between calculated and observed results. A convenient synthesis of 2-hydroxy- and 4-methylamino-3-nitro-1,5- naphthyridine are reported.
