14756-77-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-1,5-naphthyridine is used as a building block for the synthesis of bioactive molecules, particularly for the development of drugs with antitumor, anticancer, and anti-inflammatory properties. Its structural similarity to purine makes it a promising candidate for the creation of new therapeutic agents.
Used in Materials Science:
3-Amino-1,5-naphthyridine is used as a component in the development of new materials with potential applications in various fields. Its unique chemical properties allow it to contribute to the creation of innovative materials with enhanced performance characteristics.
Used in Biomedical Research:
3-Amino-1,5-naphthyridine is used as a research tool to study the effects of its derivatives on various biological processes. Its potential in exhibiting antitumor, anticancer, and anti-inflammatory activities makes it an important compound for investigating new therapeutic strategies and understanding disease mechanisms.

Upstream product

• 17965-71-8 3-bromo-1,5-naphthyridine 
• 254-79-5 1,5-naphthyridine 
• 959617-73-3 tert-butyl (1,5-naphthyridin-3-yl)carbamate 
• 64222-33-9 3-nitro-1H-[1,5]naphthyridin-2-one 
• 67-56-1 methanol 
• 74919-33-8 2-chloro-3-nitro-1,5-naphthyridine 

Downstream Products

• 959617-74-4 3-fluoro-1,5-naphthyridine 

Relevant academic research and scientific papers

Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF

Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.