642409-77-6

Upstream product

• 3282-30-2 pivaloyl chloride 
• 153230-77-4 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 153230-70-7 4,4'-bis-O-(dimethyl-tert-butylsilyl)-4'-O-demethylepipodophyllotoxin 

Downstream Products

• 683805-50-7 2,2-dimethyl-propionic acid 5-(tert-butyl-dimethyl-silanyloxy)-7-cyanomethyl-8-(4-hydroxy-3,5-dimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-6-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of podophyllotoxin analogues: δ-lactone-containing picropodophyllin, podophyllotoxin and 4′-demethyl-epipodophyllotoxin derivatives

Non-epimerizable cis and trans δ-lactone analogues of podophyllotoxin have been prepared. Thus the synthesis of the cis isomer 4 has been achieved in 8 steps and 4% overall yield from podophyllotoxin 1 via the reduction of the γ lactone ring into the tran

Synthesis and antiproliferative activity of retroetoposide

Retro-4′-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4′-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-β-D- glucoside 26 afforded retroetoposide 5 which is