64241-77-6

Basic information

• Product Name: 3-Fluoro-2,2-dimethyl-propionic acid
• Synonyms: 3-Fluoro-2,2-dimethyl-propionic acid;3-Fluoro-2,2-diMethylpropanoic acid;Propanoic acid, 3-fluoro-2,2-dimethyl-
• CAS NO: 64241-77-6
• Molecular Formula: C5H9FO2
• Molecular Weight: 120.1221632
• Mol File: 64241-77-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 190.6°C at 760 mmHg
• Flash Point: 69.1°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: 1.399
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-2,2-dimethyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-2,2-dimethyl-propionic acid(64241-77-6)
• EPA Substance Registry System: 3-Fluoro-2,2-dimethyl-propionic acid(64241-77-6)

Safety Data

• RIDADR: 3261
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 64241-77-6(Hazardous Substances Data)

Usage

General Description

3-Fluoro-2,2-dimethyl-propionic acid, also known as FDMPA, is a chemical compound with the molecular formula C6H11FO2. It is a colorless liquid with a pungent odor and is soluble in water. FDMPA is used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also utilized as a building block for the synthesis of various organic compounds. FDMPA is classified as a hazardous substance and should be handled and stored with caution to prevent exposure and environmental contamination.

InChI:InChI=1/C5H9FO2/c1-5(2,3-6)4(7)8/h3H2,1-2H3,(H,7,8)

Upstream product

• 1068560-15-5 methyl 3-fluoro-2,2-dimethylpropanoate 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 17701-61-0 benzyl 2,2-dimethyl-3-hydroxypropanoic acid 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 

Relevant articles and documents

Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study

Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

ORGANIC COMPOUNDS

The present invention relates to a compound of formula (I) (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.