17701-61-0

Basic information

• Product Name: BENZYL 3-HYDROXY-2,2-DIMETHYLPROPANOATE
• Synonyms: BENZYL 3-HYDROXY-2,2-DIMETHYLPROPANOATE;Benzyl 3-Hydroxy-2,2-dimethylpropionate
• CAS NO: 17701-61-0
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25
• Mol File: 17701-61-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: BENZYL 3-HYDROXY-2,2-DIMETHYLPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 3-HYDROXY-2,2-DIMETHYLPROPANOATE(17701-61-0)
• EPA Substance Registry System: BENZYL 3-HYDROXY-2,2-DIMETHYLPROPANOATE(17701-61-0)

Safety Data

• Hazardous Substances Data: 17701-61-0(Hazardous Substances Data)

Upstream product

• 1301764-12-4 cesium salt of 2,2-dimethyl-3-hydroxypropionic acid 
• 100-39-0 benzyl bromide 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 7285-83-8 2,4,6-tris(benzyloxy)-1,3,5-triazine 
• 21620-60-0 2-methylglyceric acid 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 

Downstream Products

• 1337544-05-4 benzyl 3-(2-cyano-3-nitrophenoxy)-2,2-dimethylpropanoate 
• 1379613-69-0 3-(benzyloxy)-2,2-dimethyl-3-oxopropyl thiophene-2-carboxylate 
• 1379614-04-6 3-(benzoyloxy)-2,2-dimethylpropyl benzoate 
• 64241-77-6 β-Fluoro-pivalic acid 
• 1955-45-9 pivalolactone 
• 1531585-26-8 benzyl 2-cyclopropyl-2-methylpropanoate 
• 1447942-30-4 benzyl 3,3-difluoro-2,2-dimethylpropanoate 
• 1337544-04-3 benzyl 3-(3-amino-2-cyanophenoxy)-2,2-dimethylpropanoate 
• 661480-83-7 4-(2-benzyloxycarbonyl-2-methylpropoxy)benzaldehyde 
• 464189-13-7 N-(2-cyclohexylcarbamoyl-2-methyl-propoxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionamide 
• 464189-17-1 N-cyclohexyl-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionamide 

Relevant articles and documents

Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study

Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.

Piperazine adenosine monophosphate activated protein kinase (AMPK) agonist and medical application thereof

The invention discloses a piperazine compound with AMPK agonist activity, and a preparation method and medical application of the piperazine compound. The piperazine compound is a compound shown as aformula (I) (please see the specifications for the formula), and a pharmaceutically acceptable salt or ester or a prodrug or N-oxide or solvate thereof. The compound can be used for preparing drugs for preventing or treating AMPK-mediated diseases.

O-Benzylation of Carboxylic Acids Using 2,4,6-Tris(benzyloxy)-1,3,5-triazine (TriBOT) under Acidic or Thermal Conditions

Two methods for the synthesis of benzyl esters from carboxylic acids using the O-benzylating reagent 2,4,6-tris(benzyloxy)-1,3,5-triazine (TriBOT) have been developed. The reactions were conducted either in the presence of a catalytic amount of TfOH at room temperature (acidic conditions) or in the absence of TfOH at 180-230 C (thermal conditions). Interestingly, the O-benzylation of hydroxy carboxylic acids under the two conditions afforded different products: The dibenzylated product under acidic conditions and the hydroxy ester under thermal conditions. In addition to these results, other evidence indicated that the former reaction proceeds through an SN1-type mechanism, and the latter by an SN2-type mechanism. Two methods for the O-benzylation of carboxylic acids using TriBOT have been developed under either acidic or thermal conditions. The O-benzylation of hydroxy carboxylic acids afforded the dibenzylated product under acidic conditions and the hydroxy ester under thermal conditions. The former reaction proceeds through an SN1-type mechanism and the latter by an SN2-type mechanism.