64287-25-8Relevant academic research and scientific papers
N-Heterocyclic carbene-palladacyclic complexes: synthesis, characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides
Liu, Feng,Hu, Yuan-Yuan,Li, Di,Zhou, Quan,Lu, Jian-Mei
, p. 5683 - 5690 (2018)
N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01 mol%).
New synthesis of tetraoxaspirododecane-diamines and tetraoxazaspirobicycloalkanes
Makhmudiyarova, Nataliya N.,Shangaraev, Kamil R.,Dzhemileva, Lilya U.,Tyumkina, Tatyana V.,Mescheryakova, Ekaterina S.,D'Yakonov, Vladimir A.,Ibragimov, Askhat G.,Dzhemilev, Usein M.
, p. 29949 - 29958 (2019/10/01)
An efficient method for the synthesis of new spiro-tetraoxadodecanediamines and tetraoxazaspirobicycloalkanes has been developed by reactions of primary arylamines with gem-dihydroperoxides and α,ω-dialdehydes (glyoxal, pentanedial) catalyzed by lanthanid
n-Butyllithium-mediated synthesis of N-aryl tertiary amines by reactions of fluoroarenes with secondary amines at room temperature
Lin, Yingyin,Li, Meng,Ji, Xinfei,Wu, Jingjing,Cao, Song
, p. 1466 - 1472 (2017/02/18)
A simple and facile method for the synthesis of aromatic tertiary amines by amination of fluoroarenes with secondary amines in the presence of n-butyllithium at room temperature was reported.
Amination of aryl bromides catalysed by supported palladium
Djakovitch, Laurent,Wagner, Michael,Koehler, Klaus
, p. 225 - 234 (2007/10/03)
Palladium particles immobilised onto a metal oxide support or Pd(0), Pd(II) and [Pd(NH3)4]2+ in NaY zeolite have been prepared and characterised. They exhibit a good activity towards the amination of aryl bromides using secondary amines such as piperidine and diethyl amine with a good regio-selectivity for these reactions. Low Pd concentrations (1 mol%) are required to observe a reasonable regio-selectivity. The catalysts can easily be separated from the reaction mixture (filtration) and reused without loss of activity and selectivity. The electronic nature of the aryl halides plays an important role for both the reaction yields and the regio-control of the reaction. It depends on the relation of the direct amination via a benzyne intermediate versus the Pd-catalysed route.
