642993-70-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 643727-57-5 (-)-phenyl (2R,3R)-4-benzyloxy-3-(tert-butyldimethylsiloxy)-2-methylbutyrate 
• 642993-64-4 (-)-phenyl (2R,3R)-4-benzyloxy-3-hydroxy-2-methylbutanoate 
• 642993-51-9 1-(1H-benzotriazol-1-yl)-2-benzyloxyethan-1-one 
• 501419-25-6 (+)-(2S,3R)-4-benzyloxy-3-(tert-butyldimethylsiloxy)-2-methylbutan-1-ol 
• 426833-07-0 (-)-(2R,3R)-4-benzyloxy-3-hydroxy-2-methyl-1-phenyl-butan-1-one 
• 426833-01-4 4-benzyloxy-2-methyl-1-phenylbutane-1,3-dione 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 30379-55-6 benzyloxyacetic acid 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 642993-67-7 (2R,3R)-4-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-2-methylbutanal 

Downstream Products

• 642993-74-6 2-[(1S,2R,3S,4R)-5-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-pentyl]-[1,3]dithiane 
• 643727-58-6 (+)-(2S,3R,4S,5R)-6-benzyloxy-3,5-bis(tert-butyldimethylsiloxy)-2,4-dimethyl-N-methoxy-N-methylhexanamide 
• 643727-59-7 (+)-(2S,3R,4S,5R)-6-benzyloxy-3,5-bis(tert-butyldimethylsiloxy)-2,4-dimethylhexanal 
• 642993-72-4 (+)-(2S,3R,4S,5R)-6-benzyloxy-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,4-dimethyl-N-methoxy-N-methylhexanamide 

Relevant academic research and scientific papers

Enantioselective monoreduction of 2-alkyl 1,3-diketones using chiral ruthenium catalysts. Synthesis of the C14-C25 fragment of bafilomycin A 1

The enantioselective monoreduction of 2-alkyl 1,3-diketones by dynamic kinetic resolution using optically active ruthenium catalysts allowed the preparation of the C14-C25 fragment of bafilomycin A1.

Synthesis of the C14-C25 Subunit of Bafilomycin A1

The enantioselective synthesis of the C14-C25 subunit of bafilomycin A 1, was realized in a convergent route. The sequence involves two dynamic kinetic resolution steps of 2-alkyl 1,3-diketones that use optically active ruthenium complexes, an