64328-69-4

Upstream product

• 37592-72-6 1-(4-hexyl-phenyl)-ethanone 
• 50606-95-6 4-hexylbenzoyl chloride 

Downstream Products

• 81539-66-4 4-(4-Hexyl-phenyl)-N¹-[1-phenyl-meth-(Z)-ylidene]-imidazole-1,2-diamine 
• 81539-61-9 C₄₄H₄₈N₈ 
• 1359983-62-2 C₁₅H₂₁N₃*ClH 
• 1359983-80-4 C₂₀H₂₉N₃O₂ 
• 81539-74-4 11-(4-Hexyl-phenyl)-9,9a,12,13-tetraaza-cyclopenta[b]triphenylene 
• 81539-72-2 6-(4-Hexyl-phenyl)-imidazo[1,2-b][1,2,4]triazine 
• 81539-69-7 4-(4-hexylphenyl)imidazole-1,2-diamine 

Relevant academic research and scientific papers

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

We recently reported a 2-aminoimidazole-based antibiotic adjuvant that reverses colistin resistance in two species of Gram-negative bacteria. Mechanistic studies in Acinetobacter baumannii demonstrated that this compound downregulated the PmrAB two-compon

1-phenyl-2-phenylaminoethyl ketone derivative and medical application

The invention belongs to the field of pharmaceutical chemicals, and relates to a micromolecular inhibitor of polymyxin drug-resistant protein MCR-1 and application thereof. The invention relates to acompound shown as a formula I, a pharmaceutically accept

Design, synthesis and biological evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors

Polymyxins are considered to be the last-line antibiotics that are used to treat infections caused by multidrug-resistant (MDR) gram-negative bacteria; however, the plasmid-mediated transferable colistin resistance gene (mcr-1) has rendered polymyxins ine

Small molecule suppression of carbapenem resistance in ndm-1 producing klebsiella pneumoniae

The already considerable global public health threat of multidrug-resistant Gram-negative bacteria has become even more of a concern following the emergence of New Delhi metallo-β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-negative bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole-derived small molecule that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae to imipenem and meropenem, in addition to suppressing resistance of other β-lactam nonsusceptible K. pneumoniae strains. The small molecule is able to lower carbapenem minimum inhibitory concentrations by up to 16-fold, while exhibiting little bactericidal activity itself.

PHENACYL ESTERS - A NEW TYPE OF LUQUID-CRYSTALLINE COMPOUND

The reaction of aliphatic, alicyclic, and aromatic acids with 4-substituted α-bromoacetophenones gave a series of new liquid-crystalline phenacyl esters.Their mesomorphous characteristics are discussed in relation to the structures of the acid and ketone parts of the molecule.

Synthesis of 1,2-diamino imidazole derivatives by the reaction of benzaldehyde guanylhydrazone with α-haloalkyl aryl ketones

2-Amino-1-benzylideneamino-4-arylimidazoles were obtained by the reaction of benzaldehyde guanylhydrazone with 4-alkyl- and 4-aryl-Ω-haloacetophenones. Side products of this reaction were cis- and trans-1,1′-bis(benzylideneamino)-4,4′-diaryl-2,2′-azoimida