50606-95-6

Usage

Uses

Used in Chemical Synthesis:
4-N-HEXYLBENZOYL CHLORIDE is used as a chemical intermediate for the synthesis of various organic compounds. Its application is primarily due to its reactivity and ability to form new bonds with other molecules, leading to the creation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-N-HEXYLBENZOYL CHLORIDE is used as a key component in the synthesis of certain drugs. Its role is to provide the necessary chemical structure that can be further modified or combined with other molecules to create effective pharmaceutical agents.
Used in Material Science:
4-N-HEXYLBENZOYL CHLORIDE is also utilized in the field of material science, where it is employed in the development of new materials with specific properties. Its chemical structure allows it to be incorporated into polymers, coatings, and other materials, enhancing their performance and functionality.
Used in Research and Development:
4-N-HEXYLBENZOYL CHLORIDE is an important compound in research and development, where it is used to explore new chemical reactions and develop innovative applications. Its versatility and reactivity make it a valuable tool for scientists and researchers working on various projects.

InChI:InChI=1/C13H17ClO/c1-2-3-4-5-6-11-7-9-12(10-8-11)13(14)15/h7-10H,2-6H2,1H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 1077-16-3 hexylbenzene 
• 21643-38-9 4-hexylbenzoic acid 
• 942-92-7 caprophenone 
• 142-61-0 Hexanoyl chloride 
• 71-43-2 benzene 

Downstream Products

• 71979-75-4 4-Hexyl-thiobenzoic acid S-(4-propyl-phenyl) ester 
• 64408-94-2 4-Hexyl-thiobenzoic acid S-(4-hexyl-phenyl) ester 
• 64357-31-9 (4-Hexyl-phenyl)-(4-propyl-phenyl)-methanone 
• 64357-30-8 4-Butyl-4-hexyl-benzophenon 
• 64408-95-3 4-Hexyl-thiobenzoic acid S-(4-hexyloxy-phenyl) ester 
• 64577-99-7 4-Hexyl-thiobenzoic acid S-(4-butoxy-phenyl) ester 
• 64408-96-4 4-Hexyl-thiobenzoic acid S-(4-cyano-phenyl) ester 
• 72997-60-5 2-(4-hexylphenyl)-5-(4-methoxyphenyl)-1,3-thiazole 
• 72997-64-9 5-(4-ethoxy-phenyl)-2-(4-hexyl-phenyl)-thiazole 
• 72997-65-0 2-(4-hexyl-phenyl)-5-(4-propoxy-phenyl)-thiazole 
• 59748-36-6 4-n-hexylbenzoic acid 4'-(4-n-pentylphenyl)-phenyl ester 
• 64357-89-7 4-(n-Hexyl)-2',4',6'-trimethylbenzophenone 
• 49763-69-1 4-hexylbenzaldehyde 
• 89094-40-6 norethisterone 4-hexylbenzoate 

Relevant academic research and scientific papers

Spiropyrane derivative with color, fluorescence and liquid crystal property triple switching effects as well as preparation method and application thereof

The invention discloses a spiropyrane derivative with color, fluorescence and liquid crystal property triple switching effects as well as a preparation method and application of the spiropyrane derivative. The spiropyrane derivative is prepared by esterification reaction of 1',3',3'-trimethyl-6-nitrospiro[benzopyran-2,2'-dihydroindole]-5', 8-diol and alkyl / alkoxy substituted benzoic acid with alkyl / alkoxy group at para-position or acrylate / methacrylate group at the chain end. The spiropyran derivative is used as a molecular switch in a smart material. The spiropyran derivative has responsiveness to light, heat, pH value and force, has triple switchable effects of color, fluorescence and liquid crystal property, has significant difference in response behaviors in different chemical environments, and is suitable for being used as a molecular switch in an intelligent material.

Benzyltin pyrimidine derivatives, their preparation and their use as medicaments

The invention relates to the field of pharmaceutical chemistry, specifically to benzyl pyrimidine derivatives (I), preparation methods thereof, medicinal compositions containing the derivatives and medical application of the derivatives, in particular, application of the derivatives as an immunosuppressant in autoimmune diseases and organ transplantation.

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents

The modulation of the endocannabinoid system is emerging as a viable avenue for the treatment of neurodegeneration, being involved in neuroprotective and anti-inflammatory processes. In particular, indirectly enhancing endocannabinoid signaling to therapeutic levels through FAAH inhibition might be beneficial for neurodegenerative disorders such as Alzheimer's disease, effectively preventing or slowing the progression of the disease. Hence, in the search for a more effective treatment for Alzheimer's disease, in this paper, the multitarget-directed ligand paradigm was applied to the design of carbamates able to simultaneously target the recently proposed endocannabinoid system and the classic cholinesterase system, and achieve effective dual FAAH/cholinesterase inhibitors. Among the two series of synthesized compounds, while some derivatives proved to be extremely potent on a single target, compounds 9 and 19 were identified as effective dual FAAH/ChE inhibitors, with well-balanced nanomolar activities. Thus, 9 and 19 might be considered as new promising candidates for Alzheimer's disease treatment.

Synthesis of phenanthridinones and phenanthridine derivatives through palladium-catalyzed oxidative CH coupling of benzanilides

A palladium-catalyzed oxidative CH coupling reaction of benzanilides using molecular oxygen as the oxidant furnishes phenanthridinones. The palladium-catalyzed reaction in combination with simple derivatization provides an efficient access to a phenanthridine skeleton starting from readily available benzoic acids and anilines.

Preparation of new substituted bis(benzoyl) peroxides under aqueous conditions in the presence of stearyltrimethylammonium chloride

A series of new substituted bis(benzoyl) peroxides has been synthesised from their corresponding acid chlorides in high yield. The reactions were carried out in aqueous sodium peroxide solution and butanone in the presence of 0.5% stearyltrimethylammonium chloride (STAC) at a temperature below 15°C. STAC improved the purity, and the fast addition improved the yield of the peroxides. Mass spectral analysis of substituted bis(benzoyl) peroxides using EI has been carried out for accurate mass determinations. Springer-Verlag 2003.

Physicochemical parameters involved in the lethal toxicity of N,N-[(dimethylamino)ethyl]-4-substituted benzoate hydrochlorides: A QSAR study

A set of sixteen para-substituted N,N-[(dimethylamino)ethyl] benzoate hydrochlorides structurally related to procaine was synthesized. The apparent partition coefficients were determined by either shake-flask or HPLC methods and were taken as hydrophobic parameters. The IR stretching frequencies of the carbonyl group were determined in chloroform and taken as one of the electronic parameters. Additional physicochemical parameters were either taken from the literature: π, a, J and R, MR4, or calculated: log P. The lethal potency was determined in the mouse via the LD50. In order to verify the nature and the relative contributions of the physicochemical parameters to lethal toxicity, QSAR equations were derived using regression analysis. A major contribution of hydrophobicity together with a smaller but still significant contribution of electronic or polar properties was found to describe the toxicity within this set of compounds.

SYNTHESIS AND LIQUID CRYSTAL PROPERTIES OF SUBSTITUTED 5-(ARYLCARBONYLOXY)-2-(p-CYANOPHENYL)PYRIMIDINES

Liquid crystal p-substituted benzoates, biphenylcarboxylates, and benzoyloxybenzoates were obtained on the basis of 5-hydroxy-2-(p-cyanophenyl)pyrimidine.The development of nematogenicity by the esters due to the p-cyanophenyl grouping was noted, and the appearance of the smectic mesophase by the variation of the ring framework of the acid fragment of the molecule was investigated.

Orientation of the benzophenone group at various depths in bilayers

The hydrophobic core of biological membranes is primarily composed of fatty acyl chains of lipids and side chains of nonpolar amino acids belonging to membrane-spanning domains of transmembrane proteins. Electron transport across the 35-40-? membrane dielectric takes place via suitably oriented electron-transfer groups associated with transmembrane domains of membrane-bound proteins. We propose here that the design of lipids bearing electron-transport groups oriented at different depths can provide the necessary supramolecular assembly in the form of a monolayer or a bilayer to carry out electron transfer. The design of these modified lipids is crucial to the success of such a molecular device. We report here the design and synthesis of three benzophenone-based phospholipids capable of orienting the benzophenone group at different depths in a bilayer. The orientation of the benzophenone group was determined by photochemical cross-linking of these lipids with dimyristoylphosphatidylcholine in single bilayer vesicles followed by mass spectral analyses of the cross-linked products. The actual site of cross-linking on the myristoyl chain was determined, and it was observed that a range of carbon atoms are functionalized. The range of carbon atoms functionalized was found to be centered around the position expected from the transverse location of the benzophenone-based phospholipid in the bilayer. The data could be best interpreted in terms of zones of carbon atoms functionalized rather than any discreet site. This is in keeping with the current models of membranes which suggest the presence of a fluid gradient as one goes down the fatty acyl chain in the membrane. However, the range of carbon atoms functionalized was narrowed with probes reported here. The use of a hydrophobic tail attached to the benzophenone group assisted in directing the orientation of the photoactive group at different depths. Besides providing an effective design strategy for the orientation of electron-transfer groups at different depths in a bilayer, the high insertion yield and the depth-dependent labeling observed in artificial membranes suggest that the benzophenone-based phospholipids reported here could also prove useful for studying the structure of single and multiple spanning transmembrane proteins.

SYNTHESIS AND LIQUID CRYSTALLINE PROPERTIES OF 2-SUBSTITUTED (5-PYRIMIDINYL) BENZOATES AND BENZOYLOXYBENZOATES

2-Substituted (5-pyrimidinyl) benzoates and benzoyloxybenzoates have been synthesized and their liquid crystalline properties have been studied.In general, these compounds exhibit a characteristic tendency to form a smectic mesophase.

2,2'-difluoro-4-alkoxy-4'-hydroxydiphenyls and their derivatives, their production process and their use in liquid crystal display devices

The invention relates to novel compounds usable as liquid crystals in liquid crystal display devices utilizing the electrically controlled birefringence effect. These compounds comply with formula: STR1 in which R1 represents an alkoxy or alkyl radical with 1 to 12 carbon atoms and Z represents a single bond or a radical chosen from among: STR2 provided that R1 represents an alkyl radical when Z represents a single bond and R2 represents an alkyl radical with 1 to 12 carbon atoms. They can be obtained by reacting an acid chloride of formula R1 --z--COCL with a 2,2'-difluoro-4-alkoxy-4'-hydroxydiphenyl of formula: STR3