64352-98-3

Basic information

• Product Name: Benzene, [[2-(2-chloroethoxy)ethoxy]methyl]-
• CAS NO: 64352-98-3
• Molecular Formula: C11H15ClO2
• Molecular Weight: 214.692
• Mol File: 64352-98-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzene, [[2-(2-chloroethoxy)ethoxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [[2-(2-chloroethoxy)ethoxy]methyl]-(64352-98-3)
• EPA Substance Registry System: Benzene, [[2-(2-chloroethoxy)ethoxy]methyl]-(64352-98-3)

Safety Data

• Hazardous Substances Data: 64352-98-3(Hazardous Substances Data)

Upstream product

• 628-89-7 2-(2-Chloroethoxy)ethanol 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 7285-83-8 2,4,6-tris(benzyloxy)-1,3,5-triazine 
• 100-39-0 benzyl bromide 
• 2050-25-1 diethylene glycol monobenzyl ether 

Downstream Products

• 99700-24-0 2-<5-(Benzyloxy)-3-oxapentyloxy>phenol-(tetrahydro-2-pyranylether) 
• 341527-11-5 1-{4-[2-(2-benzyloxyethoxy)ethoxy]phenyl}-2-phenylethanone 
• 88454-84-6 (2R,3R)-N,N,N',N'-Tetramethyl-2,3-bis<2-<2-(benzyloxy)ethoxy>ethyl>tataramide 
• 99700-23-9 2,2'-<1,2-Phenylenbis(oxy)-2,1-ethandiyloxy>bisethanol-dibenzylether 
• 99700-22-8 2-<5-(Benzyloxy)-3-oxapentyloxy>phenol 
• 88454-83-5 ((2-(2-iodoethoxy)ethoxy)methyl)benzene 
• 60389-48-2 C₂₄H₃₄O₆ 
• 64352-85-8 2-(3-Trifluoromethyl-phenylamino)-benzoic acid 2-(2-benzyloxy-ethoxy)-ethyl ester 

Relevant articles and documents

Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species

A new triazine-based cationic leaving group has been developed for the acid-catalyzed alkylation of O- and C-nucleophiles. There are two synergistic driving forces, namely, stable C=O bond formation and charge-charge repulsive effects, involved in the rapid generation of the carbocation species in the presence of trifluoromethanesulfonic acid (～200 mol %). Considerable rate acceleration of benzylation, allylation, and p-nitrobenzylation was observed as compared to the reactions with less than 100 mol % of the acid catalyst. The triazine-based leaving group showed superior p-nitrobenzylation yield and stability in comparison to common leaving groups, trichloroacetimidate and bromide. A plausible reaction mechanism (the cationic leaving group pathway) was proposed on the basis of mechanistic and kinetic studies, NMR experiments, and calculations.

Specific reactivity of 2,4,6-tri-tert-butylanilide anions and its application to benzylation reagent

The reaction of methyl iodide with an anilide anion prepared from 2,4,6-tri-tert-butylanilide and NaH in CH3CN gave N-methyl anilide (N-alkylation product) as a major product, while in the reaction of benzyl bromide with the anilide anion in DMF, O-benzyl imidate (O-alkylation product) was obtained with almost complete selectivity. The treatment of O-benzyl imidate with alcohols and carboxylic acids in the presence of trifluoromethane sulfonic acid gave benzyl ethers and benzyl esters, respectively.

TRIAZINE DIONE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel triazine dione compound useful as an alkylating agent for a nucleophilic compound. SOLUTION: This invention relates to a compound represented by formula (I) [where each symbol is as defined in the specification] and an alkylating agent comprising the compound, and a method for alkylating a nucleophilic compound using the alkylating agent. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT