64357-41-1Relevant academic research and scientific papers
Iron-Catalyzed C(sp2)?C(sp3) Cross-Coupling of Chlorobenzamides with Alkyl Grignard Reagents: Development of Catalyst System, Synthetic Scope, and Application
Bisz, Elwira,Szostak, Michal
, p. 85 - 95 (2018/11/23)
Direct preparation of alkylated amide-derivatives by cross-coupling chemistry using sustainable protocols is challenging due to sensitivity of the amide functional group to reaction conditions. Herein, we report the synthesis of alkyl-substituted amides b
Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: A ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation
Runyon, Scott P.,Mosier, Philip D.,Roth, Bryan L.,Glennon, Richard A.,Westkaemper, Richard B.
experimental part, p. 6808 - 6828 (2009/10/17)
The effects of 3-position substitution of 9-aminomethy 1-9,10- dihydroanthracene (AMDA) on 5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1-(2,5-dimethoxyphenyl)-2- aminopropanes substituted at the 4-position. The results were interpreted within the context of 5-HT2A receptor models that suggest that members of the DOB-like series can bind to the receptor in two distinct modes that correlate with the compounds' functional activity. Automated ligand docking and molecular dynamics suggest that all of the AMDA derivatives, the parent of which is a 5-HT2A antagonist, bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds. The failure of the F340 6.52L mutation to adversely affect the affinity of AMDA and the 3-bromo derivative is consistent with the proposed modes of orientation. Evaluation of ligand-receptor complex models suggest that a valine/threonine exchange between the 5-HT2A and D2 receptors may be the origin of selectivity for AMDA and two substituted derivatives.
Regioselective Functionalization of Nonactivated CH-Bonds, 4. -Photoreactions of Amphiphilic Derivatives of Benzophenonecarboxylic Acid and Myristic Acid Derivatives in Micelles and Bilayers
Gogoll, Adolf,Schaefer, Hans J.
, p. 597 - 606 (2007/10/02)
Amphiphilic derivatives of benzophenonecarboxylic acid and myristic acid in micelles, vesicles, and multilamellar aggregates were photochemically converted into tertiary alcohols, the workup of which yielded mixtures of the isomeric ketomyristic acid methyl esters 5.A slightly increased but none the less low selectivity was found in bilayers in comparison with micelles.Various amphiphilic head groups shifted the center of attack.Low total yields, especially in bilayers, can be attributed to a predominant reaction between the benzophenone substituents.By preparation of the corresponding reference compounds it could be demonstrated that benzhydrols (8a-d) or benzpinacols (9a-c) are not formed in this unexpected reaction.
