64357-71-7

Basic information

• Product Name: Methanone, phenyl(2,3,4,6-tetramethylphenyl)-
• CAS NO: 64357-71-7
• Molecular Formula: C17H18O
• Molecular Weight: 238.329
• Mol File: 64357-71-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl(2,3,4,6-tetramethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl(2,3,4,6-tetramethylphenyl)-(64357-71-7)
• EPA Substance Registry System: Methanone, phenyl(2,3,4,6-tetramethylphenyl)-(64357-71-7)

Safety Data

• Hazardous Substances Data: 64357-71-7(Hazardous Substances Data)

Upstream product

• 2142-78-1 1-(2,3,4,6-tetramethyl-phenyl)-ethanone 
• 98-88-4 benzoyl chloride 
• 527-53-7 1,2,3,5-Tetramethylbenzene 
• 65-85-0 benzoic acid 
• 618-32-6 Benzoyl bromide 

Downstream Products

• 155785-79-8 1-acetyl-2-(nitrooxymethyl)-4,5,6-trimethylbenzene 
• 78740-45-1 1-acetyl-3-nitro-2,4,5,6-tetramethylbenzene 
• 103224-55-1 2-(nitromethyl)-4,5,6-trimethylacetophenone 
• 91390-77-1 1-propionyl-2,4,5,6-tetramethylbenzene 
• 69187-00-4 1,5-dipropionyl-2,3,4,6-tetramethylbenzene 
• 69313-51-5 1,3-diacetyl-2,4,5,6-tetramethylbenzene 
• 527-53-7 1,2,3,5-Tetramethylbenzene 
• 65-85-0 benzoic acid 
• 854247-35-1 1-phenyl-1-(2,3,4,6-tetramethyl-phenyl)-ethene 
• 2142-78-1 1-(2,3,4,6-tetramethyl-phenyl)-ethanone 

Relevant articles and documents

Graphite as an effective catalyst for Friedel-Crafts acylation

Graphite is found to promote Friedel-Crafts acylation of aromatic compounds such as anisole, toluene and o-xylene with acyl halides to give the corresponding acylated products in high yields.

2-(Trifluoromethylsulfonyloxy)pyridine as a Reagent for the Ketone Synthesis from Carboxylic Acids and Aromatic Hydrocarbons

A new reagent 2-(trifluoromethylsulfonyloxy)pyridine (TFOP) was prepared by the reaction of sodium salt of 2-pyridinol with trifluoromethylsulfonyl chloride in dioxane.The conpound TFOP in trifluoroacetic acid has been found to intermolecularly dehydrate from benzoic acid and aromatic hydrocarbons to give the corresponding benzophenones in high yield.It was further elucidated, in the reaction of fluorene, that a variety of carboxylic acids can be used as the acyl precursor for the aromatic ketone synthesis in conjunction with the TFOP/TFA system.This acylation procedure has been applied to the synthesis of 2-acylthiophenes, which are hard to prepare in a satisfactory yield by the classical Friedel-Crafts reaction using aluminum chloride as the catalyst.