64358-50-5

Basic information

• Product Name: 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN
• Synonyms: aminomethyltrioxsalen;4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN;4'-AMINOMETHYLTRIOXSALENE;Trioxsalen, 4-Aminomethyl-, HCl;(3H)4'-Aminomethyl-4,5',8-trimethylpsoralen;3-(Aminomethyl)-2,5,9-trimethyl-7H-furo(3,2-G)(1)benzopyran-7-one;3H-Amt;5-Amtp
• CAS NO: 64358-50-5
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.28
• Mol File: 64358-50-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: 1 mg/mL
• CAS DataBase Reference: 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN(64358-50-5)
• EPA Substance Registry System: 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN(64358-50-5)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34-40
• Safety Statements: 26-27-36-36/37/39-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 64358-50-5(Hazardous Substances Data)

Usage

Uses

4''-Aminomethyl-4,5'',8-trimethylpsoralen is a bioactive molecule able to intercalates into double-stranded DNA.

Upstream product

• 62442-58-4 4'-N-Phthalimidomethyl-4,5',8-trimethylpsoralen 
• 3902-71-4 trioxsalen 
• 62442-57-3 4'-chloromethyl-4,5',8-trimethylpsoralen 

Downstream Products

• 1404289-17-3 C₅₄H₆₀N₅O₁₀P 
• 1404289-16-2 C₄₅H₄₃N₃O₉ 

Relevant articles and documents

Design and Application of Mini-libraries of miRNA Probes for an Efficient and Versatile miRNA-mRNA Cross-linking

MicroRNAs constitute a class of endogenous, non-coding RNAs that influence various processes within the cell. By base-pairing to partially-complementary sites located in the 3’ untranslated region of target messenger RNAs, microRNAs participate in post-transcriptional regulation of the majority of human protein-coding genes. Their dysregulation has been related to many pathological processes and diseases. Thus, an in-depth understanding of the microRNA mechanisms of action is crucial. Here, we present a new concept of probe design to achieve an efficient and sequence-independent miRNA-mRNA cross-linking. The new strategy is based on the utilization of a controlled mixture of probes for a chosen miRNA, in which a trioxsalen moiety is introduced at the N4-position of a selected cytidine through short oligoethylene glycol-based linkers. In vitro photo-cross-linking experiments with mini-libraries of probes for microRNAs of interest showed variable cross-linking efficiencies, demonstrating a general applicability of the presented approach.

Aminomethyl psoralens. Electrophilic substitutions of hydroxymethylphthamide on linear furocoumarins

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