6436-61-9

Basic information

• Product Name: 4-Thiazolecarboxylic acid, 2-[(benzoylamino)methyl]-, methyl ester
• CAS NO: 6436-61-9
• Molecular Formula: C13H12N2O3S
• Molecular Weight: 276.316
• Mol File: 6436-61-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Thiazolecarboxylic acid, 2-[(benzoylamino)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylic acid, 2-[(benzoylamino)methyl]-, methyl ester(6436-61-9)
• EPA Substance Registry System: 4-Thiazolecarboxylic acid, 2-[(benzoylamino)methyl]-, methyl ester(6436-61-9)

Safety Data

• Hazardous Substances Data: 6436-61-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 70-23-5 ethyl Bromopyruvate 
• 55443-42-0 N-(2-amino-2-thioxoethyl)benzamide 
• 5692-27-3 2-benzamido-ethanenitrile 
• 98-88-4 benzoyl chloride 
• 98-91-9 thiobenzoic acid 
• 50-00-0 formaldehyd 
• 72130-98-4 (Z)-1-(dimethylamino)-3-methoxy-N-methylidyne-3-oxoprop-1-en-2-aminium 
• 10450-13-2 2-(benzoylamino-methyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester 
• 186581-53-3 diazomethane 
• 93404-54-7 2-(benzamidomethyl)thiazole-4-carboxylic acid 

Downstream Products

• 174149-05-4 2-(benzamidomethyl)-4-carbamoyl>thiazole 
• 174149-06-5 2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole 
• 93404-54-7 2-(benzamidomethyl)thiazole-4-carboxylic acid 

Relevant articles and documents

A new and efficient multicomponent solid-phase synthesis of 2-acylaminomethylthiazoles

A new multicomponent reaction (MCR) for the preparation of 2-substituted thiazole libraries using Rink amide resin is described. Thiazoles are assembled in a one-pot MCR of a thiocarboxylic acid, aldehyde, 3-(N,N-dimethylamino)-2-isocyanoacrylate with a resin-bound primary amine. Aliphatic and aromatic thiocarboxylic acids as well as aliphatic and (hetero-) aromatic aldehydes work in the reaction. Cleavage of the product yields the substituted thiazoles in reasonable to good purity.

Peptides. XXI. Dehydrogenation of some thiazolines derived from cysteine.

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