64370-14-5

Upstream product

• 64370-13-4 [(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-oxo-acetic acid 4-nitro-benzyl ester 
• 64370-26-9 methyl (2R,3R)-2-(2'-benzothiazolylthio)-α-isopropylidene-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate 
• 4888-90-8 phenoxymethylpenicillin sulfoxide 
• 10209-03-7 methyl 6β-phenoxyacetamidopenicillanate-1β-sulfoxide 
• 40578-84-5 methyl (2R,3R)-2-(benzothiazol-2'-yldithio)-α-isopropenyl-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate 
• 64370-08-7 p-nitrobenzyl (2R,3R)-2-(benzothiazol-2'-yldithio)-α-isopropylidene-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate 
• 64370-60-1 [(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-oxo-acetic acid methyl ester 

Relevant academic research and scientific papers

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R is hydrogen, R or R4 where R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or Beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

Improved Procedure for Conversion of Penicillin V into Monocyclic β-Lactams

Improved procedures for the preparation of the Kamiya compound (3R,4R)-4-(benzothiazol-2'-yldithio)-3-phenoxyacetamidoazetidin-2-one (6) from penicillin V (1) are described.A novel feature is ozonolysis, near room temperature, in aqueous methanol in the p

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R" is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula ?OR5, or ?S-S-R5 wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

2-Penem compounds

The invention relates to 6-amino-2-penem-3-carboxylic acid compounds of the formula STR1 in which R1a denotes hydrogen or an amino protective group R1A and R1b represents hydrogen or an acy