64372-62-9

Basic information

• Product Name: 2-Chloro-5-(trifluoromethyl)benzyl alcohol
• Synonyms: 2-CHLORO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL;RARECHEM AL BD 0369;2-Chloro-5-Trifluoromethyl Benzylalcohol 2-Chloro-5-(Trifluoromethyl)benzyl Alcohol;2-Chloro-5-(trifluoromethyl)benzyl alcohol, 97+%;4-Chloro-3-(hydroxymethyl)benzotrifluoride;Jrd-1184;[2-chloro-5-(trifluoroMethyl)phenyl]Methanol;4-Chloro-3-(hydroxymethyl)benzotrifluoride, [2-Chloro-5-(trifluoromethyl)phenyl]methanol
• CAS NO: 64372-62-9
• Molecular Formula: C₈H₆ClF₃O
• Molecular Weight: 210.58
• Product Categories: Alcohol;Alcohols;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Fluorine series
• Mol File: 64372-62-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 57-60°C
• Boiling Point: 227.1°C at 760 mmHg
• Flash Point: 110°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 0.0446mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: 2-Chloro-5-(trifluoromethyl)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-(trifluoromethyl)benzyl alcohol(64372-62-9)
• EPA Substance Registry System: 2-Chloro-5-(trifluoromethyl)benzyl alcohol(64372-62-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 64372-62-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H6ClF3O/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-3,13H,4H2

Upstream product

• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 
• 82386-89-8 2-chloro-5-(trifluoromethyl)benzaldehyde 
• 22902-87-0 1-chloro-2-(chloromethyl)-4-(trifluoromethyl)benzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 

Downstream Products

• 22902-87-0 1-chloro-2-(chloromethyl)-4-(trifluoromethyl)benzene 
• 82386-89-8 2-chloro-5-(trifluoromethyl)benzaldehyde 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 
• 1575721-50-4 1-chloro-2-(((4-methoxybenzyl)oxy)methyl)-4-(trifluoromethyl)benzene 
• 875548-98-4 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl 
• 1383676-73-0 1-chloro-2-(methoxymethyl)-4-(trifluoromethyl)benzene 

Relevant articles and documents

A 2-halo-5-trifluoromethylbenzoate methyl animal pen alcoholic compound preparation method

The invention relates to the field of a medical intermediate, and particularly discloses a preparation method of intermediate 2-halogenate-5-trifluoromethyl benzyl alcohol of a novel cholesterol-lowering medicament, namely a cholesteryl ester transfer protein (CETP) inhibitor. The method comprises the following steps: carrying out chloromethylation reaction and esterification reaction on 4-halogenated trifluorotoluene used as a raw material, and then carrying out hydrolysis reaction so as to obtain a product 2-halogenate-5-trifluoromethyl benzyl alcohol compound. The method disclosed by the invention is available in raw materials, low in cost, environment-friendly and energy-saving, simple in process, easy for realization of industrialization, high in product yield, good in purity and stable in quality, and completely accords with the operating requirements on the medical intermediate.