64379-45-9

Basic information

• Product Name: [1,8]NAPHTHYRIDINE-2-CARBALDEHYDE
• Synonyms: IFLAB-BB F1926-0010;[1,8]NAPHTHYRIDINE-2-CARBALDEHYDE
• CAS NO: 64379-45-9
• Molecular Formula: C₉H₆N₂O
• Molecular Weight: 158.16
• Mol File: 64379-45-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 331.3 °C at 760 mmHg
• Flash Point: 158.5 °C
• Appearance: /
• Density: 1.299 g/cm³
• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.69±0.30(Predicted)
• CAS DataBase Reference: [1,8]NAPHTHYRIDINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: [1,8]NAPHTHYRIDINE-2-CARBALDEHYDE(64379-45-9)
• EPA Substance Registry System: [1,8]NAPHTHYRIDINE-2-CARBALDEHYDE(64379-45-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 64379-45-9(Hazardous Substances Data)

Usage

General Description

[1,8]Naphthyridine-2-carbaldehyde is a chemical compound with the molecular formula C12H7NO. It belongs to the class of naphthyridine derivatives and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. [1,8]Naphthyridine-2-carbaldehyde has been studied for its potential biological activities, including its antimicrobial and anticancer properties. It is also used as a reagent in organic synthesis and as a building block in the preparation of various heterocyclic compounds. The chemical structure of [1,8]Naphthyridine-2-carbaldehyde contains a naphthyridine ring with a carbaldehyde functional group, making it a versatile compound for the development of new drugs and materials.

InChI:InChI=1/C9H6N2O/c12-6-8-4-3-7-2-1-5-10-9(7)11-8/h1-6H

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 7521-41-7 2-Aminonicotinaldehyde 
• 67-64-1 acetone 
• 1569-16-0 2-methyl-[1,8]naphthyridine 
• 125902-27-4 2-(Hydroxymethyl)-1,8-naphthyridine 

Downstream Products

• 204452-90-4 2-(dimethoxymethyl)-1,8-naphthyridine 
• 215523-34-5 1,8-naphthyridine-2-carboxylic acid 
• 1377187-98-8 N-(2-6-diisopropylphenyl)-1-(1,8-naphthyridin-2-yl)methanimine 

Relevant articles and documents

High-selectivity fibroblast growth factor receptor inhibitor and application

The invention discloses a high-selectivity fibroblast growth factor receptor inhibitor and application, and particularly relates to a compound shown in a formula (I) or a pharmaceutically acceptable salt, a solvate, a geometric isomer, a stereoisomer, a tautomer and any mixture thereof. The compound shown in the formula (I) or the pharmaceutically acceptable salt, the solvate and the pharmaceutical composition thereof can be applied to prevention or treatment of diseases related to FGFR4 activity or overexpression, and can also be combined with other medicines to be used for treating various related diseases, especially for treating various cancers, wherein the cancers may be liver cancer, lung cancer, gastric cancer, breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma, skin cancer, colon cancer, bile duct cancer, glioma or sarcoma.

Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.