64380-53-6

Basic information

• Product Name: 1,3-Dioxolane, 2-(3-chlorophenyl)-
• CAS NO: 64380-53-6
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Mol File: 64380-53-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(3-chlorophenyl)-(64380-53-6)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(3-chlorophenyl)-(64380-53-6)

Safety Data

• Hazardous Substances Data: 64380-53-6(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Application

Solvent in the manufacturing of perfumes, dyes, and personal care products

Hazardous nature

Yes, can cause skin and eye irritation upon contact

Safety precautions

Handle with caution, store and handle in a well-ventilated area, use appropriate personal protective equipment (PPE) when working with it

Upstream product

• 107-21-1 ethylene glycol 
• 587-04-2 m-Chlorobenzaldehyde 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 19800-47-6 3,3'-diformyl-1,1'-biphenyl 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 118350-17-7 4'-methoxy-[1,1'-biphenyl]-3-carbaldehyde 
• 19693-78-8 2-(3-methoxyphenyl)-1,3-dioxolane 
• 587-04-2 m-Chlorobenzaldehyde 
• 1400692-86-5 2-(3-chloro-2-methylphenyl)-1,3-dioxolane 
• 1400692-88-7 2-chloro-6-(1,3-dioxolan-2-yl)-N,N-dimethylbenzamide 
• 1400692-89-8 2-chloro-6-(1,3-dioxolan-2-yl)-N-ethylbenzamide 
• 1400692-87-6 ethyl 2-chloro-6-(1,3-dioxolan-2-yl)benzoate 
• 1400692-91-2 2-chloro-6-(1,3-dioxolan-2-yl)benzamide 
• 1379324-65-8 2-[3-chloro-2-(methylsulfanyl)phenyl]-1,3-dioxolane 
• 874-27-1 3-Chloro-2-methylbenzaldehyde 
• 70097-44-8 7-chloro-3-hydroxyisobenzofuran-1(3H)-one 
• 1400692-85-4 2-(3-chloro-2-iodophenyl)-1,3-dioxolane 

Relevant articles and documents

Synthesis method of m-methoxybenzyl alcohol

The invention discloses a synthesis method of m-methoxybenzyl alcohol. The synthesis method comprises the steps: (1) by taking ethylene glycol and m-chlorobenzaldehyde as raw materials and sulfuric acid as a catalyst, carrying out condensation reaction in a solvent to prepare ethylene glycol condensed m-chlorobenzaldehyde; (3) dissolving the ethylene glycol condensed m-chlorobenzaldehyde in an organic solvent to obtain a mixed solution; (4) adding a condensing agent into the mixed solution under a stirring condition, and heating for reaction to form a reaction system containing ethylene glycol condensed m-methoxybenzaldehyde; (5) evaporating to remove the organic solvent in the reaction system, then cooling, adjusting the pH value of the system, and carrying out phase splitting on the reaction system after the pH value is adjusted to obtain an organic phase I; (6) adding a catalyst and a metal reducing agent into the organic phase I, resolving acetal and reducing to obtain a reaction solution containing a crude product of m-methoxybenzyl alcohol; and (7) continuing to split phases of the reaction liquid to obtain an organic phase II, and washing, drying and rectifying the organic phase II to obtain refined m-methoxybenzyl alcohol.

House bulb light-induced photochemical acetalization of carbonyl compounds catalyzed by Eosin Y

We have systematically studied the reactions of acetalization and found that high reaction efficiency can be achieved using cheap and readily available organic Eosin Y as catalyst. The reaction proceeds smoothly under house bulbs and shows excellent functional group tolerance. The substrates of the reaction system are compatible with aromatic aldehydes, aliphatic aldehydes, aromatic ketones, and cyclic ketones with high yields.

Acetalization of aldehydes and ketones over H4[SiW 12O40] and H4[SiW12O 40]/SiO2

H4[SiW12O40] (H-SiW12) is demonstrated to be able to efficiently catalyze the acetalization of aldehydes and ketones with ethylene glycol and 1,3-propanediol. Nevertheless, the possible leaching and the recycling of H-SiW12 are two major disadvantages that largely restrict its further application in industry. Moreover, H 4[SiW12O40] tends to deactivate strong proton sites due to the small surface area of 10 m2 g-1. Due to interactions with surface silanol groups, the proton sites of polyoxometalates (POMs) on SiO2 are less susceptible to deactivation. As such, immobilization of H4[SiW12O40] onto SiO 2 leads to the heterogeneous catalyst H4[SiW 12O40]/SiO2 (H-SiW12/SiO 2), which can catalyze the acetalization of aldehydes and ketones with ethylene glycol and 1,3-propanediol selectively and efficiently without the need of a drying agent. The acetalization process can proceed smoothly at a relatively low temperature under solvent-free conditions. The catalyst of H 4[SiW12O40]/SiO2 can be recycled at least ten times without an obvious decrease in its catalytic activity. As far as we know, the TONs of the H-SiW12/SiO2-catalyzed acetalization of cyclohexanone with ethylene glycol, and benzaldehyde with 1,3-propanediol are the highest reported so far.