70097-44-8

Basic information

• Product Name: 7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE
• Synonyms: 7-Chloro-3-hydroxyisobenzofuran-1(3H)-one;7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE
• CAS NO: 70097-44-8
• Molecular Formula: C₈H₅ClO₃
• Molecular Weight: 184.58
• Mol File: 70097-44-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE(70097-44-8)
• EPA Substance Registry System: 7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE(70097-44-8)

Safety Data

• Hazardous Substances Data: 70097-44-8(Hazardous Substances Data)

Upstream product

• 20771-97-5 2-chloro-6-formyl-benzoic acid 
• 124-38-9 carbon dioxide 
• 3395-80-0 1,1-dimethoxy-1-(3-chlorophenyl)methane 
• 70097-45-9 7-chloroisobenzofuran-1(3H)-one 
• 587-04-2 m-Chlorobenzaldehyde 
• 1400692-87-6 ethyl 2-chloro-6-(1,3-dioxolan-2-yl)benzoate 
• 64380-53-6 2-(3-chlorophenyl)-1,3-dioxolane 
• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 10345-79-6 N,N-Diethyl-2-chlorobenzamide 

Relevant articles and documents

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-π interactions and not the previously considered cation/π-π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Functionalization of 3-chlorobenzaldehyde

2-Substituted 3-chlorobenzaldehydes were prepared from the corresponding 2-(3-chlorophenyl)-1,3-dioxolanes using an ortho-lithiation strategy. The 6-chloro-2-formylbenzamide exists only in a ring form, but 6-chloro-2- formylbenzoic acid esters were isolated in both forms as open chain and cyclic tautomers. 7-Chloro-3-hydroxy-3H-isobenzofuran-1-one reacted with nucleophilic reagents at the carbonyl or quaternary carbon depending on the character of nucleophile. Georg Thieme Verlag Stuttgart New York.

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2, 1-a]isoindol-6(2H)-one, a selective, orally active agonist of the 5-HT 2C receptor

Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone- containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a] isoindol-6(2H)-one (58), a 5-HT2C agonist with > 300-fold functional selectivity over 5-HT2B and > 70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.