874-27-1

Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-2-methylbenzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Agrochemical Industry:
3-chloro-2-methylbenzaldehyde serves as a building block in the production of agrochemicals, aiding in the development of effective and environmentally friendly solutions for agriculture.
Used in Dye Production:
3-chloro-2-methylbenzaldehyde is used as a starting material in the synthesis of dyes, enabling the creation of a wide range of colorants for various applications.
Used in Fragrance Industry:
As a component in the production of fragrances, 3-chloro-2-methylbenzaldehyde contributes to the development of unique and complex scents for perfumes and other scented products.
Used in Specialty Chemicals:
This versatile compound is also utilized in the production of specialty chemicals, enhancing the properties and performance of various industrial products.

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 74-88-4 methyl iodide 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 90369-75-8 (3-chloro-2-methyl-phenyl)methanol 
• 1400692-86-5 2-(3-chloro-2-methylphenyl)-1,3-dioxolane 
• 64380-53-6 2-(3-chlorophenyl)-1,3-dioxolane 
• 118-69-4 2,6-dichlorotoluene 
• 75-17-2 formaldoxime 
• 87-60-5 3-chloro-2-methylbenzenamine 

Downstream Products

• 879-51-6 3-Chlor-2-methyl-zimtsaeure 
• 1188271-84-2 1-(3-chloro-2-methylphenyl)-2-phenylethanamine 
• 879-50-5 3-(3-chloro-2-methylphenyl)propanoic acid 
• 90369-81-6 3,3'-bis(bromomethyl)-2,2'-dimethylbenzophenone 
• 90369-88-3 Bis(3-(mercaptomethyl)-2-methylphenyl) Ketone 
• 90369-93-0 C₁₉H₂₄N₄OS₂⁽²⁺⁾*2Br^(1-) 
• 90369-79-2 Bis(3-(methoxymethyl)-2-methylphenyl)methanol 
• 90369-82-7 Bis(3-(methoxymethyl)-2-methylphenyl)methane 
• 90369-80-5 Bis(3-(methoxymethyl)-2-methylphenyl) Ketone 
• 90369-83-8 Bis(3-(bromomethyl)-2-methylphenyl)methane 
• 90369-84-9 Bis(3-(mercaptomethyl)-2-methylphenyl)methane 
• 90369-78-1 3-(Methoxymethyl)-2-methylbenzonitrile 
• 90369-77-0 2-Chloro-6-(methoxymethyl)toluene 
• 90369-76-9 1-(bromomethyl)-3-chloro-2-methyl benzene 

Relevant academic research and scientific papers

Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes

A sequential one-pot process for chemoselectively reducing sterically demanding N,N-diisopropylamides to aldehydes has been developed. In this reaction, amides are activated with EtOTf to form imidates, which are reduced with LiAlH(OR)3 [R = t-Bu, Et] to give aldehydes by hydrolysis of the resulting hemiaminals. The non-nucleophilic base 2,6-DTBMP remarkably improves reaction efficiency. The combination of EtOTf/2,6-DTBMP and LiAlH(O-t-Bu)3 was found to be optimal for reducing alkyl, alkenyl, alkynyl, and 2-monosubstituted aryl N,N-diisopropylamides. In contrast, EtOTf and LiAlH(OEt)3 in the absence of base were found to be optimal for reducing extremely sterically demanding 2,6-disubstituted N,N-diisopropylbenzamides. The reaction tolerates various reducible functional groups, including aldehyde and ketone. 1H NMR studies confirmed the formation of imidates stable in water. The synthetic usefulness of this methodology was demonstrated with N,N-diisopropylamide-directed ortho-metalation and C-H bond activation.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Functionalization of 3-chlorobenzaldehyde

2-Substituted 3-chlorobenzaldehydes were prepared from the corresponding 2-(3-chlorophenyl)-1,3-dioxolanes using an ortho-lithiation strategy. The 6-chloro-2-formylbenzamide exists only in a ring form, but 6-chloro-2- formylbenzoic acid esters were isolated in both forms as open chain and cyclic tautomers. 7-Chloro-3-hydroxy-3H-isobenzofuran-1-one reacted with nucleophilic reagents at the carbonyl or quaternary carbon depending on the character of nucleophile. Georg Thieme Verlag Stuttgart New York.

INHIBITORS OF MONOAMINE UPTAKE

N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

Ortho Metalation Directed by α-Amino Alkoxides

The addition of aromatic aldehydes to certain lithium dialkylamides in benzene or tetrahydrofuran gave α-amino alkoxides which were ortho lithiated with excess n-butyllithium.Subsequent alkylation and hydrolysis provided ortho-substituted aromatic aldehydes via a one-pot reaction.The ortho metalation of α-amino alkoxides derived from 1- and 2-naphthaldehyde and various substituted benzaldehydes was examined.When N,N,N'-trimethylethylenediamine was used as the amine component of the α-amino alkoxide, metalation could be carried out at lower temperatures.This rate increase is due to an intramolecular TMEDA-like assisted metalation.The synthetic utility of this ortho metalation, including how varying the amine component of the α-amino alkoxide affects the regiochemistry and metalation rate, is discussed.

Syntheses and Reactions of the First Dithiametacyclophanes, Metacyclophanes, and Metacyclophanedienes

Two new cyclophane series, the dithiametacyclophanes 5 and the metacyclophanedienes 6, are synthesized and their chemistry is described.On the basis of this chemistry, such cyclophanes appear not to adopt the syn or anti conformations fo

Substituted imidazo thiazoles thiazines, thiazepines and thiazocines

Disclosed herein are novel tetrahydro imidazo thiazoles, tetrahydro imidazo thiazines, hexahydro imidazo thiazepines and hexahydro imidazo thiazocines, intermediates for the preparation thereof, methods of using the compounds as anti-inflammatory agents and methods of using an intermediate thereof as anti-secretory agents to relieve the symptoms of gastric distress.