64389-27-1

Upstream product

• 6489-59-4 Phenyl penicillin 
• 98-88-4 benzoyl chloride 
• 551-16-6 6-Aminopenicillanic Acid 

Downstream Products

• 51415-31-7 C₂₈H₂₆N₂O₅S 
• 1427682-95-8 C₂₃H₂₈N₂O₆ 
• 1427682-96-9 C₂₂H₂₂N₂O₇ 
• 1427682-97-0 C₂₂H₂₂N₂O₇ 
• 1427682-98-1 C₂₂H₂₃N₃O₆ 
• 1427682-93-6 C₂₁H₂₆N₂O₆ 
• 1427682-92-5 C₂₀H₂₄N₂O₆ 
• 1427682-85-6 C₁₇H₂₀N₂O₆ 
• 1427682-84-5 C₃₀H₃₁ClN₂O₆ 
• 1427683-25-7 C₃₄H₃₁N₃O₈ 
• 1427683-26-8 C₃₄H₃₁N₃O₈ 
• 1427683-23-5 C₃₆H₃₇N₃O₉ 
• 1427683-24-6 C₃₆H₃₇N₃O₉ 
• 78037-17-9 (R)-3-Chloromethyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester 

Relevant academic research and scientific papers

The new convenient synthesis of novel γ-alkylidenebutenolides from 6-aminopenicillanic acid

Butenolides have good biological activity and serve as the important unit of pharmaceutical intermediates, of which γ-alkylidenebutenolides have gained wide attention over the last past decades particularly. A simple and practical method for the synthesis of butenolide 6 and its 5-substituted analogues 7a-t via vinylogous aldol reaction from 6-aminopenicillanic acid (6-APA) with the ratio of Z/E isomers between 1.1/1.0 and 1.0/0 under mild conditions in 6 steps was first reported. Besides, we also reported the methanolysis behaviors of azetidinone fused oxazoline derivatives. All the synthesized γ-alkylidenebutenolides are new and are currently being evaluated for their biological activities.