6489-59-4

Upstream product

• 551-16-6 6-Aminopenicillanic Acid 
• 98-88-4 benzoyl chloride 
• 102770-08-1 Cyclohexa-2,5-dienoyl-L-cysteinyl-D-valine 

Downstream Products

• 60049-45-8 Phenyl penicillin methyl ester 
• 1427682-95-8 C₂₃H₂₈N₂O₆ 
• 1427682-96-9 C₂₂H₂₂N₂O₇ 
• 1427682-97-0 C₂₂H₂₂N₂O₇ 
• 1427682-98-1 C₂₂H₂₃N₃O₆ 
• 1427682-99-2 C₂₃H₂₄N₂O₇ 
• 1427683-00-8 C₂₃H₂₄N₂O₇ 
• 1427683-01-9 C₂₇H₃₀N₂O₉ 
• 1427683-02-0 C₂₇H₃₀N₂O₉ 
• 1427683-03-1 C₂₆H₂₆N₂O₆ 
• 1427683-04-2 C₂₆H₂₆N₂O₆ 
• 51415-31-7 C₂₈H₂₆N₂O₅S 
• 1427683-05-3 C₂₆H₂₉N₃O₆ 
• 1427683-06-4 C₂₆H₂₉N₃O₆ 

Relevant academic research and scientific papers

Reagents with a Crystalline Coat

Tetrakis(dimethoxyphenyl)adamantane (TDA) readily forms crystalline inclusion complexes with reactive, toxic, or malodorous reagents, such as benzoyl chloride, acetyl chloride, cyclohexyl isocyanide, phosphorus trichloride, and trimethylsilyl chloride. The crystals are stable and largely free of the problematic properties of the free reagents. When exposed to solvents such as DMSO or MeOH, the reagents react, and a large portion of the TDA precipitates. The TDA-coated reagents may lead to a safer way of storing, handling, and delivering reagents, and ultimately to synthetic protocols that do not require fume hoods.

The new convenient synthesis of novel γ-alkylidenebutenolides from 6-aminopenicillanic acid

Butenolides have good biological activity and serve as the important unit of pharmaceutical intermediates, of which γ-alkylidenebutenolides have gained wide attention over the last past decades particularly. A simple and practical method for the synthesis of butenolide 6 and its 5-substituted analogues 7a-t via vinylogous aldol reaction from 6-aminopenicillanic acid (6-APA) with the ratio of Z/E isomers between 1.1/1.0 and 1.0/0 under mild conditions in 6 steps was first reported. Besides, we also reported the methanolysis behaviors of azetidinone fused oxazoline derivatives. All the synthesized γ-alkylidenebutenolides are new and are currently being evaluated for their biological activities.

Reasons for structure-acid resistance correlation in series of substituted phenylpenicillins

The kinetics of acid hydrolysis of phenylpenicillins substituted in the benzene ring were studied at pH 3.0 and temperatures of 20, 25, and 30°C. A Hammett correlation analysis of the reaction was performed.

Penicillin Biosynthesis: Direct Biosynthetic Formation of Penicillin V and Penicillin G

The enzyme isopenicillin N synthetase is able to convert directly the dipeptides, phenoxyacetylcysteinylvaline and phenylacetylcysteinylvaline into penicillin V and G respectively; these are however very slow compared with substrates of the α-aminoadipoyl or adipoylcysteinylvaline type.