644-26-8Relevant articles and documents
Aminomethyltriorganotin compounds, preferably α-mono or disubstituted; and the method of preparation
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, (2008/06/13)
The invention concerns a method of preparation of aminomethyltriorganotin compounds, preferably α-mono or disubstituted, the new tin compounds obtained thereby and an application of said tin compounds to the synthesis of aminomethylorganometallic compounds and to the regiospecific preparation of β-aminoalcohols. The intermediate tin and metallic compounds are new. The method for preparing the tin compounds comprises reacting an iminium salt with a corresponding stannylanion, preferably a triorganostannylanion. This method provides best yields and provides regiospecific β-aminoalcohols useful by having in most cases a large spectrum of pharmacological activities.