64400-49-3

Basic information

• Product Name: 2,5-DIMETHYL-P-ANISONITRILE
• Synonyms: 2,5-DIMETHYL-P-ANISONITRILE;2,5-DIMETHYL-PARA-ANISONITRILE
• CAS NO: 64400-49-3
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 64400-49-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-DIMETHYL-P-ANISONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-P-ANISONITRILE(64400-49-3)
• EPA Substance Registry System: 2,5-DIMETHYL-P-ANISONITRILE(64400-49-3)

Safety Data

• Hazardous Substances Data: 64400-49-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5473, 1984 DOI: 10.1016/S0040-4039(01)81602-6

Upstream product

• 64400-50-6 4-Methoxy-2,5-dimethyl-benzaldehyde oxime 
• 75-05-8 acetonitrile 
• 1706-11-2 2,5-Dimethyl-anisol 
• 6745-75-1 2,5-dimethyl-p-anisaldehyde 

Downstream Products

• 168405-44-5 C₁₀H₁₅NO 
• 1027302-67-5 4,5-dihydro-4-hydroxy-2-(4-methoxy-2,5-dimethylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole 

Relevant articles and documents

Acetonitrile as a cyanating reagent: Cu-catalyzed cyanation of arenes

A novel approach to the Cu-catalyzed cyanation of simple arenes using acetonitrile as an attractive cyano source has been documented. The C-H functionalization of arenes without directing groups involves a sequential iodination/cyanation to give the desired aromatic nitriles in good yields. A highly efficient Cu/TEMPO system for acetonitrile C-CN bond cleavage has been discovered. TEMPO is used as a cheap oxidant and enables the reaction to be catalytic in copper. Moreover, TEMPOCH2CN 6 has been identified as the active cyanating agent and shows high reactivity for forming the -CN moiety.

Convenient conversion of aldoximes into nitriles with N-chlorosuccinimide and pyridine

Benzaldehyde oximes substituted with electron-donating groups are dehydrated to the corresponding benzonitriles by N-chlorosuccinimide/pyridine in acetonitrile. Benzaldehyde oxime itself and alkanal oximes afford the corresponding aldehydes. Thieme Stuttgart.